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» Welcome! Welcome, NMR world! Our visitors map. » Log in User Name Remember Me? Not a member yet? Register Now! Password [NMR paper] Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR Dec 13, 2023 - 12:23 AM - by nmrlearner Activation of caspase-9 on the apoptosome as studied by methyl-TROSY NMR Mitochondrial apoptotic signaling cascades lead to the formation of the apoptosome, a 1.1-MDa heptameric protein scaffold that recruits and activates the caspase-9 protease. Once activated, caspase-9 cleaves and activates downstream effector caspases, triggering the onset of cell death through caspase-mediated proteolysis of cellular proteins. Failure to activate caspase-9 enables the evasion of programmed cell death, which occurs in various forms of cancer. Despite the critical apoptotic... More... 0 Replies | 189 Views 19F-NMR studies of the impact of different detergents and nanodiscs on the A2A adenosine receptor Dec 11, 2023 - 11:33 PM - by nmrlearner 19F-NMR studies of the impact of different detergents and nanodiscs on the A2A adenosine receptor Abstract For the A2A adenosine receptor (A2AAR), a class A G-protein-coupled receptor (GPCR), reconstituted in n-dodecyl-β-D-maltoside (DDM)/â??â??â??â??â??cholesteryl hemisuccinate (CHS) mixed micelles, previous 19F-NMR studies revealed the presence of multiple simultaneously populated conformational states. Here, we study the influence of a different detergent, lauryl maltose neopentyl glycol (LMNG) in mixed micelles with CHS, and of lipid bilayer nanodiscs on these conformational equilibria. The populations of locally different substates are pronouncedly different in DDM/â??â??â??â??â??CHS and LMNG/â??â??â??â??â??CHS micelles, whereas the A2AAR conformational manifold in LMNG/â??â??â??â??â??CHS micelles is closely similar to that in the lipid bilayer nanodiscs. Considering that nanodiscs represent a closer match of the natural lipid bilayer membrane, these observations support that LMNG/â??â??â??â??â??CHS micelles are a good choice for reconstitution trials of class A GPCRs for NMR studies in solution. Source: Journal of Biomolecular NMR 0 Replies | 159 Views [NMR paper] 19F-NMR studies of the impact of different detergents and nanodiscs on the A2A adenosine receptor Dec 11, 2023 - 11:33 PM - by nmrlearner 19F-NMR studies of the impact of different detergents and nanodiscs on the A2A adenosine receptor For the A(2A) adenosine receptor (A(2A)AR), a class A G-protein-coupled receptor (GPCR), reconstituted in n-dodecyl-?-D-maltoside (DDM)/?????cholesteryl hemisuccinate (CHS) mixed micelles, previous ^(19)F-NMR studies revealed the presence of multiple simultaneously populated conformational states. Here, we study the influence of a different detergent, lauryl maltose neopentyl glycol (LMNG) in mixed micelles with CHS, and of lipid bilayer nanodiscs on these conformational equilibria. The... More... 0 Replies | 122 Views ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein | Communications Biology - Nature.com Dec 10, 2023 - 3:59 PM - by nmrlearner ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein | Communications Biology - Nature.com ATP and nucleic acids competitively modulate LLPS of the SARS-CoV2 nucleocapsid protein | Communications Biology Nature.com Read here 0 Replies | 111 Views [NMR paper] NMR Structural Study of Syndecan-4 Transmembrane Domain with Cytoplasmic Region Dec 09, 2023 - 5:06 PM - by nmrlearner NMR Structural Study of Syndecan-4 Transmembrane Domain with Cytoplasmic Region Syndecan-4 (SDC4) consists of transmembrane heparan sulfate proteoglycan (HSPG) belonging to the syndecan family. It is present in most cell types of Mammalia. Its structure contains a heparan-sulfate-modified extracellular domain, a single transmembrane domain, and a short C-terminal cytoplasmic domain. Regarding the overall cellular function of SDC4, other cells or ligands can bind to its ecto-domain. In addition, 4,5-bisphosphate phosphatidylinositol (PIP(2)) or protein kinase C? can bind to... More... 0 Replies | 261 Views [NMR paper] Affinity measurement of strong ligands with NMR spectroscopy: Limitations and ways to overcome them Dec 09, 2023 - 5:06 PM - by nmrlearner Affinity measurement of strong ligands with NMR spectroscopy: Limitations and ways to overcome them NMR spectroscopy is currently extensively used in binding assays for hit identification, but its use in dissociation constant determination is more limited when compared to other biophysical techniques, in particular for tight binders. Although NMR is quite suitable for measuring the binding strength of weak to medium affinity ligands with dissociation constant K(D) > 1 ?M, it has some limitations in the determination of the binding strength of tight binders (K(D) < 1 ?M). A theoretical analysis... More... 0 Replies | 103 Views In-situ measurement of 3D protein structure inside living eukaryotic cells - EurekAlert Dec 08, 2023 - 12:12 PM - by nmrlearner In-situ measurement of 3D protein structure inside living eukaryotic cells - EurekAlert In-situ measurement of 3D protein structure inside living eukaryotic cells EurekAlert Read here 0 Replies | 125 Views Alexander Shekhtman: Protein Shakes - University at Albany Dec 07, 2023 - 10:35 AM - by nmrlearner Alexander Shekhtman: Protein Shakes - University at Albany Alexander Shekhtman: Protein Shakes University at Albany Read here 0 Replies | 120 Views Page 39 of 100 « First < 29 37 38 39 40 41 49 89 > Last »

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