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Bruker Introduces Novel NMR Scientific Capabilities for Structural Biology Discoveries in Membrane Proteins and ... - Yahoo Finance
Apr 21, 2024 - 7:50 AM - by nmrlearner
nmrlearner's Avatar Bruker Introduces Novel NMR Scientific Capabilities for Structural Biology Discoveries in Membrane Proteins and ... - Yahoo Finance

Bruker Introduces Novel NMR Scientific Capabilities for Structural Biology Discoveries in Membrane Proteins and ... Yahoo Finance Read here
0 Replies | 27 Views
[NMR paper] Quantification of Biopharmaceutically Relevant Nonionic Surfactant Excipients Using Benchtop qNMR
Apr 18, 2024 - 7:01 PM - by nmrlearner
nmrlearner's Avatar Quantification of Biopharmaceutically Relevant Nonionic Surfactant Excipients Using Benchtop qNMR

Nonionic surfactant excipients (NISEs) are commonly added to biologics formulations to mitigate the effects of stress incurred by the active biotherapeutic during manufacturing, transport, and storage. During manufacturing, NISEs are added by dilution of a stock solution directly into a protein formulation, and their accurate addition is critical in maintaining the quality and integrity of the drug product and thus ensuring patient safety. This is especially true for the common NISEs,...

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0 Replies | 98 Views
Characterization of membrane protein function by solid-state NMR spectroscopy - ScienceDirect.com
Apr 17, 2024 - 3:38 PM - by nmrlearner
nmrlearner's Avatar Characterization of membrane protein function by solid-state NMR spectroscopy - ScienceDirect.com

Characterization of membrane protein function by solid-state NMR spectroscopy ScienceDirect.com Read here
0 Replies | 32 Views
[NMR paper] DREAMweb: An online tool for graph-based modeling of NMR protein structure
Apr 17, 2024 - 3:38 PM - by nmrlearner
nmrlearner's Avatar DREAMweb: An online tool for graph-based modeling of NMR protein structure

The value of accurate protein structural models closely conforming to the experimental data is indisputable. DREAMweb deploys an improved DREAM algorithm, DREAMv2, that incorporates a tighter bound in the constraint set of the underlying optimization approach. This reduces the artifacts while modeling the protein structure by solving the distance-geometry problem. DREAMv2 follows a bottom-up strategy of building smaller substructures for regions with a larger concentration of experimental bounds...

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0 Replies | 116 Views
[NMR paper] Dynamics of Coordinated Phosphonate Group Directly Observed by 17O-NMR in Lanthanide(III) Complexes of a Mono(ethyl phosphonate) DOTA Analogue
Apr 17, 2024 - 3:38 PM - by nmrlearner
nmrlearner's Avatar Dynamics of Coordinated Phosphonate Group Directly Observed by 17O-NMR in Lanthanide(III) Complexes of a Mono(ethyl phosphonate) DOTA Analogue

Biological phosphates can coordinate metal ions and their complexes are common in living systems. Dynamics of mutual oxygen atom exchange in the tetrahedral group in complexes has not been investigated. Here, we present a direct experimental proof of the exchange ("phosphonate rotation") in model Ln(III) complexes of monophosphonate H4dota analogue which alters phosphorus atom chirality of coordinated phosphonate monoester. Combination of macrocycle-based isomerism with P-based chirality leads...

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0 Replies | 37 Views
[NMR paper] Unraveling the role of probiotics in affecting the structure of monoglyceride gelled emulsions: A low-field (1)H NMR study
Apr 17, 2024 - 3:38 PM - by nmrlearner
nmrlearner's Avatar Unraveling the role of probiotics in affecting the structure of monoglyceride gelled emulsions: A low-field (1)H NMR study

The capacity of monoglyceride (MG) gelled emulsions (MEs) in protecting probiotic cells of Lacticaseibacillus rhamnosus against stresses suffered during food processing, storage, and human digestion has been recently demonstrated. These findings open new perspectives on the possible participation of probiotics in the stabilization of emulsion structure. To unravel this aspect, rheological analysis and Low-Field ¹H NMR investigations were performed on MEs having different aqueous phases (water or...

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[NMR paper] SCREENES: Enhancing non-uniform sampling reconstruction for symmetrical NMR spectroscopy
Apr 14, 2024 - 12:08 AM - by nmrlearner
nmrlearner's Avatar SCREENES: Enhancing non-uniform sampling reconstruction for symmetrical NMR spectroscopy

BACKGROUND: Symmetrical NMR spectroscopy, such as Total Correlation Spectroscopy (TOCSY) and other homonuclear spectroscopy, displays symmetry in chemical shift but are generally not symmetrical in terms of intensity, which constitutes a pivotal branch of multidimensional NMR spectroscopy and offers a robust tool for elucidating the structures and dynamics of complex samples, particularly in the context of biological macromolecules. Non-Uniform Sampling (NUS) stands as a critical technique for...

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0 Replies | 300 Views
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