New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
New Protein Evolution Insight Could Improve Drug Design Drug Discovery & Development
The team used a variety of techniques to characterize the two versions of the enzyme, including X-ray crystallography and nuclear magnetic resonance, analyses of DHFR amino-acid sequences and evaluations of the enzyme's functionality in cells and in ...
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[NMR paper] Recent applications of isotopic labeling for protein NMR in drug discovery.
Recent applications of isotopic labeling for protein NMR in drug discovery.
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Expert Opin Drug Discov. 2013 Mar 12;
Authors: Hiroaki H
Abstract
Introduction: Nuclear magnetic resonance (NMR) applications in drug discovery are classified into two categories: ligand-based methods and protein-based methods. The latter is based on the observation of the (1)H-(15)N HSQC spectra of a protein with and without lead compounds. However, in order to take this...
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03-14-2013 10:05 PM
[NMR paper] Protein-Carbohydrate Interactions Studied by NMR. from Molecular Recognition to Drug Design.
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Curr Protein Pept Sci. 2012 Dec 10;
Authors: Fernandez-Alonso MD, Diaz D, Berbis MA, Marcelo F, Jimenez-Barbero J
Abstract
Diseases that result from infection are, in general, a consequence of specific interactions between a pathogenic organism and the cells. The study of host-pathogen interactions has provided insights for the design of...
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02-03-2013 10:22 AM
Researchers Look at Averting Drug Resistance - Drug Discovery & Development
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Researchers Look at Averting Drug Resistance
Drug Discovery & Development
Kern and her team studied the protein using nuclear magnetic resonance spectroscopy, adding a drug mimetic in order to learn how the structure EmrE was designed and how it functioned as it was transportingâ??moving the drug from the inside of the cell ...
Researchers Look at Averting Drug Resistance - Drug Discovery & Development
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02-02-2012 09:43 PM
3D Proteins: Getting the Big Picture - Drug Discovery & Development
3D Proteins: Getting the Big Picture - Drug Discovery & Development
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Drug Discovery & Development
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3D Proteins: Getting the Big Picture
Drug Discovery & Development
For decades, with funding from the National Science Foundation (NSF), Hinton has used nuclear magnetic resonance (NMR) to look at protein structure and function. But he wanted to find a way to educate and engage students about his discoveries. ...
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05-10-2011 07:17 PM
NMR and protein structure in drug design: application to cyclotides and conotoxins.
NMR and protein structure in drug design: application to cyclotides and conotoxins.
NMR and protein structure in drug design: application to cyclotides and conotoxins.
Eur Biophys J. 2011 Feb 3;
Authors: Daly NL, Rosengren KJ, Troeira Henriques S, Craik DJ
Nuclear magnetic resonance spectroscopy (NMR) is a powerful technique for determining the structures, dynamics and interactions of molecules, and the derived information can be useful in drug design applications. This article gives a brief overview of the role of NMR in drug design and...
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02-04-2011 11:34 AM
[NMR paper] NMR spectroscopy and protein structure determination: applications to drug discovery
NMR spectroscopy and protein structure determination: applications to drug discovery and development.
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Curr Pharm Biotechnol. 2005 Apr;6(2):105-20
Authors: Wishart D
Recent technological advances in NMR methods and instrumentation are having a significant impact in structural biology. These innovations are also impacting pharmaceutical biotechnology as it is now possible to use NMR spectroscopy to rapidly characterize a growing...
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11-25-2010 08:21 PM
Purifying Proteins: Researchers Use NMR To Improve Drug Development - Medical News To
Purifying Proteins: Researchers Use NMR To Improve Drug Development - Medical News Today (press release)
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Purifying Proteins: Researchers Use NMR To Improve Drug Development
Medical News Today (press release)
From the NMR data, they were able to determine what part and type of the protein the ligands were binding to and how strongly they would bind. ...
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10-26-2010 08:48 PM
Purifying proteins: Rensselaer researchers use NMR to improve drug development - Eure
Purifying proteins: Rensselaer researchers use NMR to improve drug development - EurekAlert (press release)
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Purifying proteins: Rensselaer researchers use NMR to improve drug development
EurekAlert (press release)
IMAGE: NMR reveals the binding sites on a protein. The more selective the ligand is at binding to a specific protein, the more efficient the process is, ...
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New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
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