Scientists uncover steps to kinase enzyme activation - Drug Target Review

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Scientists uncover steps to kinase enzyme activation - Drug Target Review

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NMR processing:

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Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

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GeNMR

I-TASSER

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Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

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d2D

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Pseudocontact shifts:

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SAVES2 or SAVES4

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FANDAS

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V-NMR

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Backbone S2

Methyl S2

B-factor

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Shiftx2

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Proshift

PPM

CheShift-2- Cα

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Poulsen_rc_CS

Disordered proteins:

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CCPN

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Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

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05-18-2018, 05:21 PM

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Scientists uncover steps to kinase enzyme activation - Drug Target Review

Drug Target Review

Scientists uncover steps to kinase enzyme activation
Drug Target Review
However, developing a drug that takes advantage of this new research finding is likely to take at least 10 years, he said. To observe a kinase called mitogen-activated protein kinase (MAPK) p38 in action, the researchers used nuclear magnetic resonance ...

Scientists uncover steps to kinase enzyme activation - Drug Target Review
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