IISc's killer discovery to fight multiple drug resistant TB bacteria - Bangalore Mirror
IISc's killer discovery to fight multiple drug resistant TB bacteria Bangalore Mirror
While the Physics department helped with crystallography of proteins and computational biology, the department of Biophysics helped with nuclear magnetic resonance (NMR) spectroscopy which found that the SD1 molecule binds to the protein. Biology ...
IISc's killer discovery to fight multiple drug resistant TB bacteria - Bangalore Mirror More...
Did you find this post helpful? |
Similar Threads
Thread
Thread Starter
Forum
Replies
Last Post
New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
<img alt="" height="1" width="1" />
New Protein Evolution Insight Could Improve Drug Design
Drug Discovery & Development
The team used a variety of techniques to characterize the two versions of the enzyme, including X-ray crystallography and nuclear magnetic resonance, analyses of DHFR amino-acid sequences and evaluations of the enzyme's functionality in cells and in ...
and more »
New Protein Evolution Insight Could Improve Drug Design - Drug Discovery & Development
More...
nmrlearner
Online News
0
10-01-2013 09:43 AM
Magic-Angle-Spinning NMR of the Drug Resistant S31N M2 Proton Transporter from Influenza A
Magic-Angle-Spinning NMR of the Drug Resistant S31N M2 Proton Transporter from Influenza A
Loren B. Andreas, Matthew T. Eddy, James J. Chou and Robert G. Griffin
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja3003606/aop/images/medium/ja-2012-003606_0001.gif
Journal of the American Chemical Society
DOI: 10.1021/ja3003606
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/47x_FMcQ9Jc
nmrlearner
Journal club
0
04-24-2012 04:39 AM
Researchers Look at Averting Drug Resistance - Drug Discovery & Development
<img alt="" height="1" width="1" />
Researchers Look at Averting Drug Resistance
Drug Discovery & Development
Kern and her team studied the protein using nuclear magnetic resonance spectroscopy, adding a drug mimetic in order to learn how the structure EmrE was designed and how it functioned as it was transportingâ??moving the drug from the inside of the cell ...
Researchers Look at Averting Drug Resistance - Drug Discovery & Development
More...
nmrlearner
Online News
0
02-02-2012 09:43 PM
[NMR paper] NMR in the acceleration of drug discovery.
NMR in the acceleration of drug discovery.
Related Articles NMR in the acceleration of drug discovery.
Curr Opin Drug Discov Devel. 2001 Jul;4(4):479-92
Authors: Sem DS, Pellecchia M
The field of NMR spectroscopy has grown beyond expectations from the first historic observation of nuclear magnetic resonance in 1946 by Bloch and Purcell, to the first generation of protein structures 20 years ago, to the present where NMR structures now represent 15 to 20% of those submitted to the Protein Data Bank (PDB). However, the applications of NMR go far...
nmrlearner
Journal club
0
11-19-2010 08:44 PM
[NMR paper] Applications of NMR in drug discovery.
Applications of NMR in drug discovery.
Related Articles Applications of NMR in drug discovery.
Drug Discov Today. 2000 Jun;5(6):230-240
Authors: Roberts GC
In the half-century since its discovery, nuclear magnetic resonance (NMR) has become the single most powerful form of spectroscopy in both chemistry and structural biology. The dramatic technical advances over the past 10-15 years, which continue apace, have markedly increased the range of applications for NMR in the study of protein-ligand interactions. These form the basis for its most...
nmrlearner
Journal club
0
11-18-2010 09:15 PM
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel.
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel.
Solution NMR structure of the V27A drug resistant mutant of influenza A M2 channel.
Biochem Biophys Res Commun. 2010 Sep 9;
Authors: Pielak RM, Chou JJ
The M2 protein of influenza A virus forms a proton-selective channel that is required for viral replication; it is also the target of the anti-influenza drugs, amantadine and rimantadine. Widespread drug-resistant mutants, however, has greatly compromised the effectiveness of these drugs. Here, we report the...
nmrlearner
Journal club
0
09-14-2010 02:03 PM
[BMNRC community] Perspectives on NMR in drug discovery: a technique comes of age
Perspectives on NMR in drug discovery: a technique comes of age
http://www.nature.com/nrd/journal/v7/n9/abs/nrd2606.html
Nature Reviews Drug Discovery 7, 738-745 (September 2008) | doi:10.1038/nrd2606
Go to BMNRC community to find more info about this topic.
nmrlearner
News from other NMR forums
0
09-02-2010 04:59 AM
[NMR paper] NMR screening in drug discovery.
NMR screening in drug discovery.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR screening in drug discovery.
Curr Opin Biotechnol. 1999 Feb;10(1):54-8
Authors: Moore JM
NMR methods in drug discovery have traditionally been used to obtain structural information for drug targets or target-ligand complexes. Recently, it has been shown that NMR may be used as an alternative approach for identification of ligands that bind to protein drug targets, shifting the emphasis...
IISc's killer discovery to fight multiple drug resistant TB bacteria - Bangalore Mirror
Linear Mode
