Electron Microscope Yields Finer Structure of Î±-Synuclein, AÎ² Fibrils - Alzforum

		BioNMR > NMR community > Online News
Electron Microscope Yields Finer Structure of Î±-Synuclein, AÎ² Fibrils - Alzforum

Webservers

NMR processing:

MDD

NMR assignment:

Backbone:

Side-chains:

NOEs:

Structure from NMR restraints:

Ab initio:

Fragment-based:

Rosetta-NMR (Robetta)

Template-based:

GeNMR

I-TASSER

Refinement:

Amber

Structure from chemical shifts:

Fragment-based:

Homology-based:

Torsion angles from chemical shifts:

Preditor

TALOS

Promega- Proline

Secondary structure from chemical shifts:

CSI (via RCI server)

TALOS

MICS caps, β-turns

d2D

PECAN

Flexibility from chemical shifts:

RCI

Interactions from chemical shifts:

HADDOCK

Chemical shifts re-referencing:

NMR model quality:

NOEs, other restraints:

Chemical shifts:

RDCs:

Pseudocontact shifts:

Protein geomtery:

SAVES2 or SAVES4

Quality Control Check

NMR spectrum prediction:

FANDAS

MestReS

V-NMR

Flexibility from structure:

Backbone S2

Methyl S2

B-factor

Molecular dynamics:

Gromacs

Amber

Antechamber

Chemical shifts prediction:

From structure:

Shiftx2

Sparta+

Camshift

CH3shift- Methyl

ArShift- Aromatic

ShiftS

Proshift

PPM

CheShift-2- Cα

From sequence:

Shifty

Camcoil

Poulsen_rc_CS

Disordered proteins:

MAXOCC

Format conversion & validation:

CCPN

From NMR-STAR 3.1

Validate NMR-STAR 3.1

NMR sample preparation:

Protein disorder:

DisMeta

Protein solubility:

Isotope labeling:

Solid-state NMR:

View First Unread

Thread Tools

Search this Thread

Rate Thread

Display Modes

09-18-2015, 11:20 PM

nmrlearner

Senior Member

Join Date: Jan 2005

Posts: 23,184

Points: 193,617, Level: 100

Level up: 0%, 0 Points needed

Activity: 50.7%

Last Achievements

Award-Showcase

NMR Credits: 0

NMR Points: 193,617

Downloads: 0

Uploads: 0

Electron Microscope Yields Finer Structure of Î±-Synuclein, AÎ² Fibrils - Alzforum

Alzforum

Electron Microscope Yields Finer Structure of Î±-Synuclein, AÎ² Fibrils
Alzforum
For many proteins, researchers obtain high-resolution structural data using nuclear magnetic resonance (NMR) spectroscopy or X-ray crystallography. However, aggregated neurodegenerative proteins do not easily form the large crystals, or homogenous ...

Electron Microscope Yields Finer Structure of Î±-Synuclein, AÎ² Fibrils - Alzforum
More...

Did you find this post helpful?

Similar Threads
Thread	Thread Starter	Forum	Replies	Last Post
[NMR paper] Further exploration of the conformational space of ?-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph. Further exploration of the conformational space of ?-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph. Related Articles Further exploration of the conformational space of ?-synuclein fibrils: solid-state NMR assignment of a high-pH polymorph. Biomol NMR Assign. 2015 Aug 30; Authors: Verasdonck J, Bousset L, Gath J, Melki R, Böckmann A, Meier BH Abstract Polymorphism is a common and important phenomenon for protein fibrils which has been linked to the appearance of strains in prion and other neurodegenerative...	nmrlearner	Journal club	0	09-01-2015 10:48 AM
NMR-EPR Combo Yields RNA-Protein Structure - The Biological SCENE NMR-EPR Combo Yields RNA-Protein Structure - The Biological SCENE http://www.bionmr.com//t0.gstatic.com/images?q=tbn:ANd9GcSUfroVOJ3Vguao95n8feL0b6T4rgW7oE8ZIpQqclY01_OIHnuCQqryfsN7sWVPrwvy3h28eog The Biological SCENE <img alt="" height="1" width="1" /> NMR-EPR Combo Yields RNA-Protein Structure The Biological SCENE The ability of the new combined NMR-EPR approach to resolve solution structures of RNA and RNA-protein complexes makes it a â??very powerfulâ?? tool, says Hashim Al-Hashimi, a biochemistry professor at Duke University School of Medicine who was not ...	nmrlearner	Online News	0	05-19-2014 09:01 AM
Monash University Orders High-End Transmission Electron Microscope from FEI ... - ThomasNet News (press release) http://www.bionmr.com//t3.gstatic.com/images?q=tbn:ANd9GcR7riFXHAZ0A2BAH2XZd6K2A4JOUU4ikdUDJIkxpcmxaSYPxPMqVbL6kHprRci2JOukf0gydw8 ThomasNet News (press release) <img alt="" height="1" width="1" /> Monash University Orders High-End Transmission Electron Microscope from FEI ... ThomasNet News (press release) World-class research facility will integrate cryo-EM with X-ray diffraction, nuclear magnetic resonance, synchrotron-based approaches and computational techniques to determine atomic structure and functional mechanisms of medically-important protein ... Monash University Orders...	nmrlearner	Online News	0	09-16-2013 05:07 PM
NMR Structure of Calmodulin Complexed to an N-TerminallyAcetylated ?-Synuclein Peptide NMR Structure of Calmodulin Complexed to an N-TerminallyAcetylated ?-Synuclein Peptide http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/bi400199p/aop/images/medium/bi-2013-00199p_0010.gif Biochemistry DOI: 10.1021/bi400199p http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA http://feeds.feedburner.com/~r/acs/bichaw/~4/MUvIOUlWswo More...	nmrlearner	Journal club	0	05-09-2013 04:04 AM
[NMR paper] Protein Structure Determination by Magic-Angle Spinning Solid-State NMR, and Insights into the Formation, Structure, and Stability of Amyloid Fibrils. Protein Structure Determination by Magic-Angle Spinning Solid-State NMR, and Insights into the Formation, Structure, and Stability of Amyloid Fibrils. Related Articles Protein Structure Determination by Magic-Angle Spinning Solid-State NMR, and Insights into the Formation, Structure, and Stability of Amyloid Fibrils. Annu Rev Biophys. 2013 Mar 22; Authors: Comellas G, Rienstra CM Abstract Protein structure determination methods using magic-angle spinning solidstate nuclear magnetic resonance (MAS SSNMR) have experienced a remarkable...	nmrlearner	Journal club	0	03-27-2013 03:33 PM
[NMR paper] Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization. Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization. http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.plosone.org-images-pone_120x30.png http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--www.pubmedcentral.nih.gov-corehtml-pmc-pmcgifs-pubmed-pmc.gif Related Articles Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization. PLoS One. 2013;8(1):e53487 Authors: ...	nmrlearner	Journal club	0	02-03-2013 10:19 AM
Under the electron microscope -- A 3-D image of an individual protein - PhysOrg.com http://www.bionmr.com//nt0.ggpht.com/news/tbn/qMGYMYLE13ZlwM/6.jpg PhysOrg.com <img alt="" height="1" width="1" /> Under the electron microscope -- A 3-D image of an individual protein PhysOrg.com Scientists routinely create models of proteins using X-ray diffraction, nuclear magnetic resonance, and conventional cryo-electron microscope (cryoEM) imaging. But these models require computer â??averagingâ?? of data from analysis of thousands, ... Under the electron microscope - a 3D image of an individual proteinNanowerk LLC all 8 news articles »	nmrlearner	Online News	0	01-26-2012 12:10 AM
Under the electron microscope - a 3D image of an individual protein - Nanowerk LLC http://www.bionmr.com//nt3.ggpht.com/news/tbn/Z0OFJYBjRagnLM/6.jpg Nanowerk LLC <img alt="" height="1" width="1" /> Under the electron microscope - a 3D image of an individual protein Nanowerk LLC C) Analysis shows how the particle structure is formed by three ApoA-1 proteins (red, green, blue noodle-like models) Scientists routinely create models of proteins using X-ray diffraction, nuclear magnetic resonance, and conventional cryo-electron ... Under the electron microscope - a 3D image of an individual protein - Nanowerk LLC	nmrlearner	Online News	0	01-25-2012 08:56 AM

« Previous Thread | Next Thread »

Posting Rules
You may not post new threads You may not post replies You may not post attachments You may not edit your posts BB code is On Smilies are On [IMG] code is On HTML code is On Trackbacks are Off Pingbacks are Off Refbacks are Off