What are the biggest differences in solving NMR structures of DNA or RNA vs. proteins?
 

What are the biggest differences in solving NMR structures of DNA or RNA vs. proteins?

I've only solved NMR structure of globular proteins (actually in a complex with a short stretch of DNA), but never a structure of nucleic acid alone.

What are (are there?) the major differences in the approaches when working on a structure of nucleic acid - in terms of choice of the NMR technique, maybe specific parameters and structure simulation?

Are distance restraints alone sufficient to obtain structure of DNA or RNA?

Thank you in advance!



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