Schmidt, R., et al., In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding. J Magn Reson, 2014. 240(0): p. 8-15.
Hyperpolarized metabolic imaging is a growing field that has provided a new tool for analyzing metabolism, particularly in cancer. Given the short life times of the hyperpolarized signal, fast and effective spectroscopic imaging methods compatible with dynamic metabolic characterizations are necessary. Several approaches have been customized for hyperpolarized (13)C MRI, including CSI with a center-out k-space encoding, EPSI, and spectrally selective pulses in combination with spiral EPI acquisitions. Recent studies have described the potential of single-shot alternatives based on spatiotemporal encoding (SPEN) principles, to derive chemical-shift images within a sub-second period. By contrast to EPSI, SPEN does not require oscillating acquisition gradients to deliver chemical-shift information: its signal encodes both spatial as well as chemical shift information, at no extra cost in experimental complexity. SPEN MRI sequences with slice-selection and arbitrary excitation pulses can also be devised, endowing SPEN with the potential to deliver single-shot multi-slice chemical shift images, with a temporal resolution required for hyperpolarized dynamic metabolic imaging. The present work demonstrates this with initial in vivo results obtained from SPEN-based imaging of pyruvate and its metabolic products, after injection of hyperpolarized [1-(13)C]pyruvate. Multi-slice chemical-shift images of healthy rats were obtained at 4.7T in the region of the kidney, and 4D (2D spatial, 1D spectral, 1D temporal) data sets were obtained at 7T from a murine lymphoma tumor model.
In vivo single-shot C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding
From The DNP-NMR Blog:
In vivo single-shot C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding
Schmidt, R., et al., In vivo single-shot C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding. J Magn Reson, 2014. 240C(0): p. 8-15.
http://www.ncbi.nlm.nih.gov/pubmed/24486720
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02-19-2014 03:12 PM
Postdoc position (in vivo hyperpolarized 13C MR)
From The DNP-NMR Blog:
Postdoc position (in vivo hyperpolarized 13C MR)
The University of Maryland School of Medicine is expanding its molecular imaging and interventional research capabilities with the addition of a Dynamic Nuclear Polarizer and High-Intensity Focused Ultrasound as part of the recently established Center for Integration of Metabolic Imaging and Therapeutics (CIMIT). This expansion is aimed to facilitate both basic science and clinical research by exploring novel molecular imaging agent based technologies for screening, early detection, and real-time...
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11-21-2013 01:14 AM
In vivo magnetic resonance imaging of hyperpolarized silicon particles
From The DNP-NMR Blog:
In vivo magnetic resonance imaging of hyperpolarized silicon particles
Cassidy, M.C., et al., In vivo magnetic resonance imaging of hyperpolarized silicon particles. Nat Nano, 2013. 8(5): p. 363-368.
http://dx.doi.org/10.1038/nnano.2013.65
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08-29-2013 01:27 AM
[NMR paper] In vivo and in vitro metabolism of a novel ?2-adrenoceptor agonist, trantinterol: metabolites isolation and identification by LC-MS/MS and NMR.
In vivo and in vitro metabolism of a novel ?2-adrenoceptor agonist, trantinterol: metabolites isolation and identification by LC-MS/MS and NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles In vivo and in vitro metabolism of a novel ?2-adrenoceptor agonist, trantinterol: metabolites isolation and identification by LC-MS/MS and NMR.
Anal Bioanal Chem. 2013 Mar;405(8):2619-34
Authors: Li K, Qin F, Jing L, Li F, Guo X
Abstract
Trantinterol...
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08-15-2013 07:45 PM
[NMR paper] A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor.
A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor.
Magn Reson Med. 2012 Dec;68(6):1705-12
Authors: Valette J, Giraudeau C, Marchadour C, Djemai B, Geffroy F, Ghaly MA, Le Bihan D, Hantraye P, Lebon V, Lethimonnier F
...
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05-31-2013 11:16 AM
Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging
From the The DNP-NMR Blog:
Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging
Nelson, S.J., et al., Strategies for rapid in vivo 1H and hyperpolarized 13C MR spectroscopic imaging. J. Magn. Reson., 2013. 229(0): p. 187-197.
http://dx.doi.org/10.1016/j.jmr.2013.02.003
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04-15-2013 08:52 AM
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging
From the The DNP-NMR Blog:
Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging
Park, J.M., et al., Metabolic response of glioma to dichloroacetate measured in vivo by hyperpolarized 13C magnetic resonance spectroscopic imaging. Neuro-Oncology, 2013. 15(4): p. 433-41.
http://neuro-oncology.oxfordjournals.org/content/early/2013/01/16/neuonc.nos319.abstract
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04-15-2013 08:52 AM
Single-shot NMR measurement of protein unfolding landscapes
Single-shot NMR measurement of protein unfolding landscapes
June 2012
Publication year: 2012
Source:Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Volume 1824, Issue 6</br>
</br>
The transient unfolding events from the native state of a protein towards higher energy states can be closely investigated by studying the process of hydrogen exchange. Here, we present BLUU-Tramp (Biophysics Laboratory University of Udine—Temperature ramp), a new method to measure the rates for the exchange process and the underlying equilibrium thermodynamic parameters, using...
In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding
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