SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

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SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

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06-12-2017, 01:48 PM

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SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

From The DNP-NMR Blog:

SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields

p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Pravdivtsev Andrey, N., SABRE Hyperpolarization of Bipyridine Stabilized Ir-Complex at High, Low and Ultralow Magnetic Fields, in Zeitschrift für Physikalische Chemie. 2017. p. 497.

https://www.degruyter.com/view/j/zpc...-2016-0810.xml

A strong limitation of nuclear magnetic resonance is its low inherent sensitivity that can be overcome by using an appropriate hyperpolarization technique. Presently, dynamic nuclear polarization and spin-exchange optical pumping are the only hyperpolarization techniques that are used in applied medicine. However, both are relatively complex in use and expensive. Here we present a modification of the signal amplification by reversible exchange (SABRE) hyperpolarization method – SABRE on stabilized Ir-complexes. A stabilized Ir-complex (here we used bipyridine for stabilization) can be hyperpolarized in a wide range of magnetic fields from a few ?T upto 10 T with 15N polarization of about 1–3%. Moreover, the investigated complex can be incorporated into biomolecules or other bulky molecules; in this situation exchange with para-hydrogen will allow one to continuously generate hyperpolarization.

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