Organic Reaction Monitoring of a Glycine Derivative Using Signal Amplification by Reversible Exchange-Hyperpolarized Benchtop Nuclear Magnetic Resonance Spectroscopy #DNPNMR #SABRE
Organic Reaction Monitoring of a Glycine Derivative Using Signal Amplification by Reversible Exchange-Hyperpolarized Benchtop Nuclear Magnetic Resonance Spectroscopy #DNPNMR #SABRE
Chae, Heelim, Sein Min, Hye Jin Jeong, Sung Keon Namgoong, Sangwon Oh, Kiwoong Kim, and Keunhong Jeong. “Organic Reaction Monitoring of a Glycine Derivative Using Signal Amplification by Reversible Exchange-Hyperpolarized Benchtop Nuclear Magnetic Resonance Spectroscopy.” Analytical Chemistry 92, no. 16 (August 18, 2020): 10902–7.
Currently, signal amplification by reversible exchange (SABRE) using para-hydrogen is an attractive method of hyperpolarization for overcoming the sensitivity problems of nuclear magnetic resonance (NMR) spectroscopy. Additionally, SABRE, using the spin order of para-hydrogen, can be applied in reaction monitoring processes for organic chemistry reactions where a small amount of reactant exists. The organic reaction monitoring system created by integrating SABRE and benchtop NMR is the ideal combination for monitoring a reaction and identifying the small amounts of materials in the middle of the reaction. We used a laboratory-built setup, prepared materials by synthesis, and showed that the products obtained by esterification of glycine were also active in SABRE. The products, which were synthesized esterified glycine with nicotinoyl chloride hydrochloride, were observed with a reaction monitoring system. The maximum SABRE enhancement among them (approximately 147-fold) validated the use of this method. This study is the first example of the monitoring of this organic reaction by SABRE and benchtop NMR. It will open new possibilities for applying this system to many other organic reactions and also provide more fruitful future applications such as drug discovery and mechanism study.
Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange
From The DNP-NMR Blog:
Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange
Kim, Sarah, Sein Min, Heelim Chae, Hye Jin Jeong, Sung Keon Namgoong, Sangwon Oh, and Keunhong Jeong. “Hyperpolarization of Nitrile Compounds Using Signal Amplification by Reversible Exchange.” Molecules 25, no. 15 (July 23, 2020): 3347.
https://doi.org/10.3390/molecules25153347.
Signal Amplification by Reversible Exchange (SABRE), a hyperpolarization technique, has been harnessed as a powerful tool to achieve useful hyperpolarized materials by polarization transfer from...
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10-19-2020 05:07 PM
Analysis of 1-aminoisoquinoline using the signal amplification by reversible exchange hyperpolarization technique #SABRE
From The DNP-NMR Blog:
Analysis of 1-aminoisoquinoline using the signal amplification by reversible exchange hyperpolarization technique #SABRE
Jeong, Hye Jin, Sein Min, and Keunhong Jeong. “Analysis of 1-Aminoisoquinoline Using the Signal Amplification by Reversible Exchange Hyperpolarization Technique.” The Analyst, 2020, 10.1039.D0AN00967A.
https://doi.org/10.1039/D0AN00967A.
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10-19-2020 05:07 PM
Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging
From The DNP-NMR Blog:
Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging
Robertson, Thomas B.R., and Ryan E. Mewis. “Perspective on the Hyperpolarisation Technique Signal Amplification by Reversible Exchange (SABRE) in NMR Spectroscopy and MR Imaging.” In Annual Reports on NMR Spectroscopy, 93:145–212. Elsevier, 2018.
https://doi.org/10.1016/bs.arnmr.2017.08.001.
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11-25-2018 06:02 AM
Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange
From The DNP-NMR Blog:
Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange
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Rayner, P.J., et al., Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange. Proc Natl Acad Sci U S A, 2017. 114(16): p. E3188-E3194.
https://www.ncbi.nlm.nih.gov/pubmed/28377523
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04-28-2017 02:27 PM
Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei
From The DNP-NMR Blog:
Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei
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Olaru, A.M., et al., Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei. Chem Commun (Camb), 2016. 52(100): p. 14482-14485.
https://www.ncbi.nlm.nih.gov/pubmed/27904890
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02-17-2017 09:56 PM
Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields
From The DNP-NMR Blog:
Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields
Pravdivtsev, A.N., et al., Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields. Appl. Magn. Reson., 2016. 47(7): p. 711-725.
http://dx.doi.org/10.1007/s00723-016-0771-y
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07-25-2016 04:26 PM
Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE)
From The DNP-NMR Blog:
Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE)
Moreno, K.X., et al., Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE). J Magn Reson, 2015. 257: p. 15-23.
http://www.ncbi.nlm.nih.gov/pubmed/26037136
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09-11-2015 07:42 PM
The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T)
From The DNP-NMR Blog:
The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T)
Barskiy, D.A., et al., The feasibility of formation and kinetics of NMR signal amplification by reversible exchange (SABRE) at high magnetic field (9.4 T). J Am Chem Soc, 2014. 136(9): p. 3322-5.
http://www.ncbi.nlm.nih.gov/pubmed/24528143
Organic Reaction Monitoring of a Glycine Derivative Using Signal Amplification by Reversible Exchange-Hyperpolarized Benchtop Nuclear Magnetic Resonance Spectroscopy #DNPNMR #SABRE
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