Diffusion-ordered NMR spectroscopy (DOSY) is a powerful approach for the analysis of molecular mixtures, yet its application range is limited by the relatively low sensitivity of NMR. We show here that spectrally resolved 13C DOSY data can be collected, in a single scan, for substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP), which provides signal enhancements of several orders of magnitude. For this we use a convection-compensation pulse scheme, which we also analyse by numerical simulation. The proposed method further allows the acquisition of several consecutive DOSY spectra in a single D-DNP experiment.
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Dynamic Nuclear Polarization Signal Amplification as a Sensitive Probe for Specific Functionalization of Complex Paper Substrates #DNPNMR
From The DNP-NMR Blog:
Dynamic Nuclear Polarization Signal Amplification as a Sensitive Probe for Specific Functionalization of Complex Paper Substrates #DNPNMR
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Gutmann, T., et al., Dynamic Nuclear Polarization Signal Amplification as a Sensitive Probe for Specific Functionalization of Complex Paper Substrates. The Journal of Physical Chemistry C, 2017. 121(7): p. 3896-3903.
http://dx.doi.org/10.1021/acs.jpcc.6b11751
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04-05-2017 02:30 PM
Journal Highlight: Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations by using SABRE hyperpolarization
Journal Highlight: Single-scan multidimensional NMR analysis of mixtures at sub-millimolar concentrations by using SABRE hyperpolarization
http://www.spectroscopynow.com/common/images/thumbnails/1513403f44e.jpgAn approach to obtain clean, SABRE-hyperpolarized 2D 1H NMR spectra of mixtures of small molecules at sub-mM concentrations in a single scan uses para-hydrogen and a deuterated co-substrate for hyperpolarization and ultrafast 2D NMR for acquisition.
Read the rest at Spectroscopynow.com
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11-30-2015 09:39 PM
[NMR paper] Liposcale: a novel advanced lipoprotein test based on 2D diffusion-ordered 1H NMR spectroscopy.
Liposcale: a novel advanced lipoprotein test based on 2D diffusion-ordered 1H NMR spectroscopy.
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J Lipid Res. 2015 Mar;56(3):737-46
Authors: Mallol R, Amigó N, Rodríguez MA, Heras M, Vinaixa M, Plana N, Rock E, Ribalta J, Yanes O, Masana L, Correig X
Abstract
Determination of...
[NMR paper] A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor.
A new sequence for single-shot diffusion-weighted NMR spectroscopy by the trace of the diffusion tensor.
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Magn Reson Med. 2012 Dec;68(6):1705-12
Authors: Valette J, Giraudeau C, Marchadour C, Djemai B, Geffroy F, Ghaly MA, Le Bihan D, Hantraye P, Lebon V, Lethimonnier F
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05-31-2013 11:16 AM
Single-scan multidimensional magnetic resonance
Single-scan multidimensional magnetic resonance
Publication year: 2010
Source:Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 57, Issue 3</br>
Assaf Tal, Lucio Frydman</br>
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Journal club
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03-09-2012 09:16 AM
Single-Scan Multidimensional Magnetic Resonance
Single-Scan Multidimensional Magnetic Resonance
Publication year: 2010
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, In Press, Accepted Manuscript, Available online 22 April 2010</br>
Assaf, Tal , Lucio, Frydman</br>
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Single-scan 13C diffusion-ordered NMR spectroscopy of DNP-hyperpolarised substrates #DNPNMR
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