NMR spectroscopy is an essential analytical technique in metabolomics and fluxomics workflows, owing to its high structural elucidation capabilities combined with its intrinsic quantitative nature. However, routine NMR “omic” analytical methods suffer from several drawbacks that may have limited their use as a method of choice, in particular when compared to another widely used technique, mass spectrometry. This review describes, in a critical and perspective discussion, how some of the most recent developments emerging from the NMR community could act as real game changers for metabolomics and fluxomics in the near future. Advanced developments to make NMR metabolomics more resolutive, more sensitive and more accessible are described, as well as new approaches to improve the identification of biomarkers. We hope that this review will convince a broad end-user community of the increasing role of NMR in the “omic” world at the beginning of the 2020s.
Nitroxides: Brief History, Fundamentals, and Recent Developments #DNPNMR
From The DNP-NMR Blog:
Nitroxides: Brief History, Fundamentals, and Recent Developments #DNPNMR
Nitroxide-based radicals are essential to many DNP-NMR experiments and a profound understanding of their chemistry is essential to synthesize new polarizing agents with increased DNP performance. This book gives a comprehensive overview of nitroxides - a good introduction for the new comer but also a reference guide for the expert.
Likhtenshtein, Gertz I. Nitroxides: Brief History, Fundamentals, and Recent Developments. Springer Series in Materials Science. Springer International...
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03-03-2020 11:18 PM
[NMR paper] NMR-Based Metabolomics of Oral Biofluids.
NMR-Based Metabolomics of Oral Biofluids.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles NMR-Based Metabolomics of Oral Biofluids.
Methods Mol Biol. 2017;1537:79-105
Authors: Schirra HJ, Ford PJ
Abstract
NMR-based metabolomics is an established technique for characterizing the metabolite profile of biological fluids and investigating how metabolite profiles change in response to biological and/or clinical stimuli. Thus,...
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01-14-2018 12:38 AM
[NMR paper] Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a)pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics.
Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a)pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics.
Toxic responses of Perna viridis hepatopancreas exposed to DDT, benzo(a)pyrene and their mixture uncovered by iTRAQ-based proteomics and NMR-based metabolomics.
Aquat Toxicol. 2017 Sep 11;192:48-57
Authors: Song Q, Zhou H, Han Q, Diao X
Abstract
Dichlorodiphenyltrichloroethane (DDT) and benzo(a)pyrene (BaP) are environmental estrogens (EEs) that are ubiquitous in the...
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09-18-2017 10:41 AM
[NMR paper] Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology.
Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology.
Related Articles Recent developments in solution nuclear magnetic resonance (NMR)-based molecular biology.
J Mol Med (Berl). 2017 Jun 23;:
Authors: Ziarek JJ, Baptista D, Wagner G
Abstract
Visualizing post-translational modifications, conformations, and interaction surfaces of protein structures at atomic resolution underpins the development of novel therapeutics to combat disease. As computational resources expand, in silico calculations...
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06-24-2017 08:20 PM
[NMR paper] NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
Related Articles NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes.
Prog Biophys Mol Biol. 2014 Aug 28;
Authors: Dias DM, Ciulli A
Abstract
Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based and fragment-based lead discovery because it is one of the most robust techniques to provide information...
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09-02-2014 11:17 PM
NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes
NMR approaches in structure-based lead discovery: Recent developments and new frontiers for targeting multi-protein complexes
Publication date: Available online 28 August 2014
Source:Progress in Biophysics and Molecular Biology</br>
Author(s): David M. Dias , Alessio Ciulli</br>
Nuclear magnetic resonance (NMR) spectroscopy is a pivotal method for structure-based and fragment-based lead discovery because it is one of the most robust techniques to provide information on protein structure, dynamics and interaction at an atomic level in solution. Nowadays, in most...
NMR-based metabolomics and fluxomics: developments and future prospects #DNPNMR
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