Matrix-free DNP-enhanced NMR spectroscopy of liposomes using a lipid-anchored biradical
From The DNP-NMR Blog:
Matrix-free DNP-enhanced NMR spectroscopy of liposomes using a lipid-anchored biradical Fernandez-de-Alba, C., et al., Matrix-free DNP-enhanced NMR spectroscopy of liposomes using a lipid-anchored biradical. Chemistry, 2015. 21(12): p. 4512-7. http://www.ncbi.nlm.nih.gov/pubmed/25663569 Magic-angle spinning dynamic nuclear polarization (MAS-DNP) has been proven to be a powerful technique to enhance the sensitivity of solid-state NMR (SSNMR) in a wide range of systems. Here, we show that DNP can be used to polarize lipids using a lipid-anchored polarizing agent. More specifically, we introduce a C16-functionalized biradical, which allows localization of the polarizing agents in the lipid bilayer and DNP experiments to be performed in the absence of excess cryo-protectant molecules (glycerol, dimethyl sulfoxide, etc.). This constitutes another original example of the matrix-free DNP approach that we recently introduced. Go to The DNP-NMR Blog for more info. |
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