Chen, L., et al., Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization. Magnetics, IEEE Transactions on, 2013. 49(7): p. 3528-3532.
Magnetic resonance force microscopy (MRFM), which combines magnetic resonance imaging with scanning probe microscopy together, is capable of performing ultra-sensitive detection of spin magnetization. In an attempt to observe dynamic nuclear polarization (DNP) in an MRFM experiment, which could possibly further improve its sensitivity towards a single proton spin, a film of perdeuterated polystyrene doped with a nitroxide electron-spin probe was prepared. A high-compliance cantilever with a 4 micrometer-diameter magnetic tip was brought near the film at a temperature of 7.3 K and in a background magnetic field of ~0.6 T. The film was irradiated with 16.7-GHz microwaves while the resulting transient change in cantilever frequency was recorded in real time. In addition to observing the expected prompt change in cantilever frequency due to saturation of the nitroxide's electron-spin magnetization, we observed a persistent cantilever frequency change. Based on its magnitude, lifetime, and field dependence, we tentatively attribute the persistent signal to polarized deuteron magnetization created via transfer of magnetization from electron spins. Further measurements of the persistent signal's dependence on the cantilever amplitude and tip-sample separation are presented and explained by the cross-effect DNP mechanism in high magnetic field gradients.
Design of a 13C magnetic resonance probe using a deuterated methoxy group as a long-lived hyperpolarization unit
From the The DNP-NMR Blog:
Design of a 13C magnetic resonance probe using a deuterated methoxy group as a long-lived hyperpolarization unit
Doura, T., et al., Design of a 13C Magnetic Resonance Probe Using a Deuterated Methoxy Group as a Long-Lived Hyperpolarization Unit. Angew. Chem. Int. Ed., 2012. 51(40): p. 10114-10117.
http://www.ncbi.nlm.nih.gov/pubmed/22961955
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04-15-2013 08:52 AM
Boosting the Sensitivityof Ligand–ProteinScreening by NMR of Long-Lived States
Boosting the Sensitivityof Ligand–ProteinScreening by NMR of Long-Lived States
Nicola Salvi, Roberto Buratto, Aure?lien Bornet, Simone Ulzega, Inmaculada Rentero Rebollo, Alessandro Angelini, Christian Heinis and Geoffrey Bodenhausen
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja303301w/aop/images/medium/ja-2012-03301w_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/ja303301w
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/xsuzyMhXJF4
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06-28-2012 07:54 AM
Long-Lived States to Monitor Protein Unfolding by Proton NMR.
Long-Lived States to Monitor Protein Unfolding by Proton NMR.
Long-Lived States to Monitor Protein Unfolding by Proton NMR.
Chemphyschem. 2011 Aug 31;
Authors: Bornet A, Ahuja P, Sarkar R, Fernandes L, Hadji S, Lee SY, Haririnia A, Fushman D, Bodenhausen G, Vasos PR
Abstract
The relaxation of long-lived states (LLS) corresponds to the slow return to statistical thermal equilibrium between symmetric and antisymmetric proton spin states. This process is remarkably sensitive to the presence of external spins and can be used to obtain...
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09-02-2011 05:40 PM
Post Doctorial position in Magnetic Resonance Force Microscopy | US Army Research Laboratory
Post Doctorial position in Magnetic Resonance Force Microscopy | US Army Research Laboratory
US - Adelphi, MD, background in one or more of biology, biochemistry, biophysics, biotechnology, organic chemistry, or structural biology with experience in (solid state) NMR. The Emerging Technologies Team of the US A
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Post Doctorial position in Magnetic Resonance Force Microscopy - US Army Research Laboratory - Washington D.C., MD, United States
Post Doctorial position in Magnetic Resonance Force Microscopy - US Army Research Laboratory - Washington D.C., MD, United States
The Emerging Technologies Team of the US Army Research Laboratory, Adelphi, MD seeks a US citizen for a post doctoral position in Magnetic Resonance Force Microscopy (MRFM) for one year, renewable for a total of three years. MRFM is force detected NMR which is orders of magnitude more sensitive than conventional electrically detected NMR enabling s...
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Magnetic Resonance Force Microscopy Detected Long-Lived Spin Magnetization
Linear Mode
