NIH Funds Development of THz resonator for solid-state DNP-NMR Probes SBIR Grant Awarded to Bridge12 for Dynamic Nuclear Polarization
Framingham, Mass. – July 18th, 2013 – Bridge12 Technologies, a leading provider of terahertz (THz) technology for applications in science, medicine, security, and defense, announces it has received a National Institute of Health’s small business innovation research (SBIR) grant for the development of a THz resonator for solid-state DNP-NMR probes. Dynamic Nuclear Polarization (DNP) can increase the sensitivity of a NMR experiment by several orders of magnitude, accelerating experiments that typically require weeks to complete in minutes.
Nuclear magnetic resonance (NMR) spectroscopy is used broadly across many disciplines, such as analytical chemistry, structural biology or drug discovery and scientists that are using NMR are often challenged by the low sensitivity of NMR, which slows down research and increases research costs.
In recent years, Dynamic Nuclear Polarization (DNP) has proven to be vastly successful in increasing sensitivity in solid-
state NMR experiments, achieving enhancement factors of > 180 at 400 MHz (1H Larmor Frequency) corresponding to a factor of 32,400 in time savings. In other words, an experiment that would otherwise run for three weeks can be performed in less than a minute. This significantly increased overall sensitivity accelerates experiments for analytical applications of NMR spectroscopy as well as the structural characterization of bio-macromolecules or pharmaceutical drug discovery.
Meet Bridge12 at ENC
From the The DNP-NMR Blog:
Meet Bridge12 at ENC
Again, the Bridge12 team is looking forward to attending this year’s 54th Experimental Nuclear Magnetic Resonance Conference (ENC) held at the Asilomar Conference Grounds in Pacific Grove from April 14th to 29th, 2013.
Let me know in advance if you would like to meet up with me (email to tmaly@bridge12.com), or simply pull me aside at the conference. I'm looking forward to this exciting event to discuss how Bridge12 can help you push the boundaries of DNP-NMR research.
Go to the The DNP-NMR Blog for more info.
Development of 43Ca NMR Solid State NMR Spectroscopy as a Probe of Local Structure in Inorganic and Molecular Materials
Development of 43Ca NMR Solid State NMR Spectroscopy as a Probe of Local Structure in Inorganic and Molecular Materials
Publication year: 2012
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Danielle Laurencin, Mark E. Smith</br>
Graphical abstract
http://origin-ars.els-cdn.com/content/image/1-s2.0-S0079656512000684-fx1.jpg Graphical abstract Highlights
nmrlearner
Journal club
0
05-17-2012 11:37 PM
[CNS Yahoo group] Trueblood Award Nominations
Trueblood Award Nominations
Dear Colleagues, on behalf of the selection committee I'd like to draw your attention to the the Trueblood award:
More...
[NMR paper] Reduction of RF-induced sample heating with a scroll coil resonator structure for sol
Reduction of RF-induced sample heating with a scroll coil resonator structure for solid-state NMR probes.
Related Articles Reduction of RF-induced sample heating with a scroll coil resonator structure for solid-state NMR probes.
J Magn Reson. 2005 Mar;173(1):40-8
Authors: Stringer JA, Bronnimann CE, Mullen CG, Zhou DH, Stellfox SA, Li Y, Williams EH, Rienstra CM
Heating due to high power 1H decoupling limits the experimental lifetime of protein samples for solid-state NMR (SSNMR). Sample deterioration can be minimized by lowering the...
New SBIR award to Bridge12 - NIH Funds Development of THz resonator for solid-state DNP-NMR Probes
Linear Mode
