BioNMR
NMR aggregator & online community since 2003
BioNMR    
Learn or help to learn NMR - get free NMR books!
 

Go Back   BioNMR > NMR community > News from NMR blogs
Advanced Search



Jobs Groups Conferences Literature Pulse sequences Software forums Programs Sample preps Web resources BioNMR issues


Webservers
NMR processing:
MDD
NMR assignment:
Backbone:
Autoassign
MARS
UNIO Match
PINE
Side-chains:
UNIO ATNOS-Ascan
NOEs:
UNIO ATNOS-Candid
UNIO Candid
ASDP
Structure from NMR restraints:
Ab initio:
GeNMR
Cyana
XPLOR-NIH
ASDP
UNIO ATNOS-Candid
UNIO Candid
Fragment-based:
BMRB CS-Rosetta
Rosetta-NMR (Robetta)
Template-based:
GeNMR
I-TASSER
Refinement:
Amber
Structure from chemical shifts:
Fragment-based:
WeNMR CS-Rosetta
BMRB CS-Rosetta
Homology-based:
CS23D
Simshift
Torsion angles from chemical shifts:
Preditor
TALOS
Promega- Proline
Secondary structure from chemical shifts:
CSI (via RCI server)
TALOS
MICS caps, β-turns
d2D
PECAN
Flexibility from chemical shifts:
RCI
Interactions from chemical shifts:
HADDOCK
Chemical shifts re-referencing:
Shiftcor
UNIO Shiftinspector
LACS
CheckShift
RefDB
NMR model quality:
NOEs, other restraints:
PROSESS
PSVS
RPF scores
iCing
Chemical shifts:
PROSESS
CheShift2
Vasco
iCing
RDCs:
DC
Anisofit
Pseudocontact shifts:
Anisofit
Protein geomtery:
Resolution-by-Proxy
PROSESS
What-If
iCing
PSVS
MolProbity
SAVES2 or SAVES4
Vadar
Prosa
ProQ
MetaMQAPII
PSQS
Eval123D
STAN
Ramachandran Plot
Rampage
ERRAT
Verify_3D
Harmony
Quality Control Check
NMR spectrum prediction:
FANDAS
MestReS
V-NMR
Flexibility from structure:
Backbone S2
Methyl S2
B-factor
Molecular dynamics:
Gromacs
Amber
Antechamber
Chemical shifts prediction:
From structure:
Shiftx2
Sparta+
Camshift
CH3shift- Methyl
ArShift- Aromatic
ShiftS
Proshift
PPM
CheShift-2- Cα
From sequence:
Shifty
Camcoil
Poulsen_rc_CS
Disordered proteins:
MAXOCC
Format conversion & validation:
CCPN
From NMR-STAR 3.1
Validate NMR-STAR 3.1
NMR sample preparation:
Protein disorder:
DisMeta
Protein solubility:
camLILA
ccSOL
Camfold
camGroEL
Zyggregator
Isotope labeling:
UPLABEL
Solid-state NMR:
sedNMR


Reply
Thread Tools Search this Thread Rate Thread Display Modes
  #1  
Unread 04-28-2017, 02:27 PM
nmrlearner's Avatar
Senior Member
 
Join Date: Jan 2005
Posts: 23,137
Points: 193,617, Level: 100
Points: 193,617, Level: 100 Points: 193,617, Level: 100 Points: 193,617, Level: 100
Level up: 0%, 0 Points needed
Level up: 0% Level up: 0% Level up: 0%
Activity: 50.7%
Activity: 50.7% Activity: 50.7% Activity: 50.7%
Last Achievements
Award-Showcase
NMR Credits: 0
NMR Points: 193,617
Downloads: 0
Uploads: 0
Default Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange

From The DNP-NMR Blog:

Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange

p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Rayner, P.J., et al., Delivering strong 1H nuclear hyperpolarization levels and long magnetic lifetimes through signal amplification by reversible exchange. Proc Natl Acad Sci U S A, 2017. 114(16): p. E3188-E3194.


https://www.ncbi.nlm.nih.gov/pubmed/28377523


Hyperpolarization turns typically weak NMR and MRI responses into strong signals so that ordinarily impractical measurements become possible. The potential to revolutionize analytical NMR and clinical diagnosis through this approach reflect this area's most compelling outcomes. Methods to optimize the low-cost parahydrogen-based approach signal amplification by reversible exchange with studies on a series of biologically relevant nicotinamides and methyl nicotinates are detailed. These procedures involve specific 2H labeling in both the agent and catalyst and achieve polarization lifetimes of ca 2 min with 50% polarization in the case of methyl-4,6-d2 -nicotinate. Because a 1.5-T hospital scanner has an effective 1H polarization level of just 0.0005% this strategy should result in compressed detection times for chemically discerning measurements that probe disease. To demonstrate this technique's generality, we exemplify further studies on a range of pyridazine, pyrimidine, pyrazine, and isonicotinamide analogs that feature as building blocks in biochemistry and many disease-treating drugs.
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica} p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica}

Go to The DNP-NMR Blog for more info.
Reply With Quote


Did you find this post helpful? Yes | No

Reply
Similar Threads
Thread Thread Starter Forum Replies Last Post
Dynamic Nuclear Polarization Signal Amplification as a Sensitive Probe for Specific Functionalization of Complex Paper Substrates #DNPNMR
From The DNP-NMR Blog: Dynamic Nuclear Polarization Signal Amplification as a Sensitive Probe for Specific Functionalization of Complex Paper Substrates #DNPNMR p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica} Gutmann, T., et al., Dynamic Nuclear Polarization Signal Amplification as a Sensitive Probe for Specific Functionalization of Complex Paper Substrates. The Journal of Physical Chemistry C, 2017. 121(7): p. 3896-3903. http://dx.doi.org/10.1021/acs.jpcc.6b11751
nmrlearner News from NMR blogs 0 04-05-2017 02:30 PM
Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei
From The DNP-NMR Blog: Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica} Olaru, A.M., et al., Using signal amplification by reversible exchange (SABRE) to hyperpolarise 119Sn and 29Si NMR nuclei. Chem Commun (Camb), 2016. 52(100): p. 14482-14485. https://www.ncbi.nlm.nih.gov/pubmed/27904890
nmrlearner News from NMR blogs 0 02-17-2017 09:56 PM
Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields
From The DNP-NMR Blog: Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields Pravdivtsev, A.N., et al., Analysis of the SABRE (Signal Amplification by Reversible Exchange) Effect at High Magnetic Fields. Appl. Magn. Reson., 2016. 47(7): p. 711-725. http://dx.doi.org/10.1007/s00723-016-0771-y
nmrlearner News from NMR blogs 0 07-25-2016 04:26 PM
Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE)
From The DNP-NMR Blog: Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE) Moreno, K.X., et al., Nuclear spin hyperpolarization of the solvent using signal amplification by reversible exchange (SABRE). J Magn Reson, 2015. 257: p. 15-23. http://www.ncbi.nlm.nih.gov/pubmed/26037136
nmrlearner News from NMR blogs 0 09-11-2015 07:42 PM
Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange
From The DNP-NMR Blog: Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange Shchepin, R.V., et al., Hyperpolarization of "Neat" Liquids by NMR Signal Amplification by Reversible Exchange. J Phys Chem Lett, 2015. 6(10): p. 1961-1967. http://www.ncbi.nlm.nih.gov/pubmed/26029349
nmrlearner News from NMR blogs 0 06-09-2015 08:18 AM
Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange
From The DNP-NMR Blog: Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange Truong, M.L., et al., Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility for NMR Signal Amplification by Reversible Exchange. The Journal of Physical Chemistry B, 2014. 118(48): p. 13882-13889. http://dx.doi.org/10.1021/jp510825b
nmrlearner News from NMR blogs 0 04-15-2015 04:40 PM
The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T)
From The DNP-NMR Blog: The Feasibility of Formation and Kinetics of NMR Signal Amplification by Reversible Exchange (SABRE) at High Magnetic Field (9.4 T) Barskiy, D.A., et al., The feasibility of formation and kinetics of NMR signal amplification by reversible exchange (SABRE) at high magnetic field (9.4 T). J Am Chem Soc, 2014. 136(9): p. 3322-5. http://www.ncbi.nlm.nih.gov/pubmed/24528143
nmrlearner News from NMR blogs 0 05-19-2014 09:25 PM
Measuring long-lived (13)C2 state lifetimes at natural abundance
From The DNP-NMR Blog: Measuring long-lived (13)C2 state lifetimes at natural abundance Claytor, K., et al., Measuring long-lived (13)C2 state lifetimes at natural abundance. J Magn Reson, 2014. 239(0): p. 81-6. http://www.ncbi.nlm.nih.gov/pubmed/24457544
nmrlearner News from NMR blogs 0 02-14-2014 05:47 PM


Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes Rate This Thread
Rate This Thread:

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are Off
Pingbacks are Off
Refbacks are Off



BioNMR advertisements to pay for website hosting and domain registration. Nobody does it for us.



Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Copyright, BioNMR.com, 2003-2013
Search Engine Friendly URLs by vBSEO 3.6.0

All times are GMT. The time now is 11:22 AM.


Map