Modular 129Xe NMR biosensor for MRI applications [Biophysics and Computational Biology]
Modular 129Xe NMR biosensor for MRI applications
Rose, H. M., Witte, C., Rossella, F., Klippel, S., Freund, C., Schroder, L....
Date: 2014-08-12
Magnetic resonance imaging (MRI) is seriously limited when aiming for visualization of targeted contrast agents. Images are reconstructed from the weak diamagnetic properties of the sample and require an abundant molecule like water as the reporter. Micromolar to millimolar concentrations of conventional contrast agents are needed to generate image contrast,... Read More
PNAS:
Number: 32
nmrlearner
Journal club
0
08-13-2014 07:49 AM
[NMR paper] Development of an antibody-based, modular biosensor for 129Xe NMR molecular imaging of cells at nanomolar concentrations.
Development of an antibody-based, modular biosensor for 129Xe NMR molecular imaging of cells at nanomolar concentrations.
Development of an antibody-based, modular biosensor for 129Xe NMR molecular imaging of cells at nanomolar concentrations.
Proc Natl Acad Sci U S A. 2014 Jul 28;
Authors: Rose HM, Witte C, Rossella F, Klippel S, Freund C, Schröder L
Abstract
Magnetic resonance imaging (MRI) is seriously limited when aiming for visualization of targeted contrast agents. Images are reconstructed from the weak diamagnetic...
nmrlearner
Journal club
0
07-30-2014 10:22 AM
Post-doc in hyperpolarized 129Xe MRI - CEA Saclay, France
From The DNP-NMR Blog:
Post-doc in hyperpolarized 129Xe MRI - CEA Saclay, France
From the Ampere Magnetic Resonance List:
A project untitled: « Polarized Xenon-MRI for diagnosis and follow up of Chest Tumors » is granted by the French programme « Projets de recherche dans le domaine de la physique, des mathématiques ou des sciences de l'ingénieur appliqués au cancer ».
nmrlearner
News from NMR blogs
0
05-16-2014 08:06 PM
[NMR paper] Molecular imaging of cancer cells using a bacteriophage-based 129Xe NMR biosensor.
Molecular imaging of cancer cells using a bacteriophage-based 129Xe NMR biosensor.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Molecular imaging of cancer cells using a bacteriophage-based 129Xe NMR biosensor.
Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4849-53
Authors: Palaniappan KK, Ramirez RM, Bajaj VS, Wemmer DE, Pines A, Francis MB
PMID: 23554263
nmrlearner
Journal club
0
10-19-2013 03:22 PM
[NMR paper] Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jan 17;
Authors: Xue S, Qiao J, Pu F, Cameron M, Yang JJ
Abstract
Magnetic...
[NMR paper] Distinguishing multiple chemotaxis Y protein conformations with laser-polarized 129Xe
Distinguishing multiple chemotaxis Y protein conformations with laser-polarized 129Xe NMR.
Related Articles Distinguishing multiple chemotaxis Y protein conformations with laser-polarized 129Xe NMR.
Protein Sci. 2005 Apr;14(4):848-55
Authors: Lowery TJ, Doucleff M, Ruiz EJ, Rubin SM, Pines A, Wemmer DE
The chemical shift of the (129)Xe NMR signal has been shown to be extremely sensitive to the local environment around the atom and has been used to follow processes such as ligand binding by bacterial periplasmic binding proteins. Here we show...
nmrlearner
Journal club
0
11-24-2010 11:14 PM
[NMR paper] Structural investigation of pig metmyoglobin by 129Xe NMR spectroscopy.
Structural investigation of pig metmyoglobin by 129Xe NMR spectroscopy.
Related Articles Structural investigation of pig metmyoglobin by 129Xe NMR spectroscopy.
Biochim Biophys Acta. 2004 Sep 24;1674(2):182-92
Authors: Corda M, Era B, Fais A, Casu M
The potentiality of xenon's sensitivity to its local magnetic environment is thoroughly investigated to probe internal structural differences between pig and horse metmyoglobin (MMb). These MMb's differ by 14 amino acids. One of these, Ile142 in horse MMb, is located in the proximal cavity, which...
Two new books: Prepolarized 129Xe-NMR, and a Fetal Imaging tome
Linear Mode
