Hadjiali, Sara, Marvin Bergmann, Alexey Kiryutin, Stephan Knecht, Grit Sauer, Markus Plaumann, Hans-Heinrich Limbach, Herbert Plenio, and Gerd Buntkowsky. “The Application of Novel Ir-NHC Polarization Transfer Complexes by SABRE.” The Journal of Chemical Physics 151, no. 24 (December 28, 2019): 244201.
In recent years, the hyperpolarization method Signal Amplification By Reversible Exchange (SABRE) has developed into a powerful technique to enhance Nuclear Magnetic Resonance (NMR) signals of organic substrates in solution (mostly via binding to the nitrogen lone pair of N-heterocyclic compounds) by several orders of magnitude. In order to establish the application and development of SABRE as a hyperpolarization method for medical imaging, the separation of the Ir-N-Heterocyclic Carbene (Ir-NHC) complex, which facilitates the hyperpolarization of the substrates in solution, is indispensable. Here, we report for the first time the use of novel Ir-NHC complexes with a polymer unit substitution in the backbone of N-Heterocyclic Carbenes (NHC) for SABRE hyperpolarization, which permits the removal of the complexes from solution after the hyperpolarization of a target substrate has been generated.
Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy #SABRE #DNP
From The DNP-NMR Blog:
Quantification of hyperpolarisation efficiency in SABRE and SABRE-Relay enhanced NMR spectroscopy #SABRE #DNP
Richardson, Peter M., Richard O. John, Andrew J. Parrott, Peter J. Rayner, Wissam Iali, Alison Nordon, Meghan E. Halse, and Simon B. Duckett. “Quantification of Hyperpolarisation Efficiency in SABRE and SABRE-Relay Enhanced NMR Spectroscopy.” Physical Chemistry Chemical Physics 20, no. 41 (2018): 26362–71.
https://doi.org/10.1039/C8CP05473H.
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05-06-2019 04:47 PM
Re-polarization of nuclear spins using selective SABRE-INEPT
From The DNP-NMR Blog:
Re-polarization of nuclear spins using selective SABRE-INEPT
Knecht, S., et al., Re-polarization of nuclear spins using selective SABRE-INEPT. Journal of Magnetic Resonance, 2018. 287: p. 10-14.
https://doi.org/10.1016/j.jmr.2017.12.010
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03-15-2018 02:05 AM
Mechanism of spontaneous polarization transfer in high-field SABRE experiments
From The DNP-NMR Blog:
Mechanism of spontaneous polarization transfer in high-field SABRE experiments
Knecht, S., et al., Mechanism of spontaneous polarization transfer in high-field SABRE experiments. Journal of Magnetic Resonance, 2018. 287: p. 74-81.
https://doi.org/10.1016/j.jmr.2017.12.018
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03-06-2018 03:16 AM
High field hyperpolarization-EXSY experiment for fast determination of dissociation rates in SABRE complexes
From The DNP-NMR Blog:
High field hyperpolarization-EXSY experiment for fast determination of dissociation rates in SABRE complexes
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Hermkens, N.K.J., et al., High field hyperpolarization-EXSY experiment for fast determination of dissociation rates in SABRE complexes. J. Magn. Reson., 2017. 276: p. 122-127.
https://doi.org/10.1016/j.jmr.2017.01.011
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05-24-2017 07:40 PM
Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE
From The DNP-NMR Blog:
Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE
Olaru, A.M., et al., Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE. Chem Commun (Camb), 2016. 52(50): p. 7842-5.
http://www.ncbi.nlm.nih.gov/pubmed/27242264
Spin polarization transfer mechanisms of SABRE: A magnetic field dependent study
From The DNP-NMR Blog:
Spin polarization transfer mechanisms of SABRE: A magnetic field dependent study
Pravdivtsev, A.N., et al., Spin polarization transfer mechanisms of SABRE: A magnetic field dependent study. J Magn Reson, 2015. 261: p. 73-82.
http://www.ncbi.nlm.nih.gov/pubmed/26529205
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04-01-2016 09:27 PM
Achieving 1% NMR polarization in water in less than 1min using SABRE
From The DNP-NMR Blog:
Achieving 1% NMR polarization in water in less than 1min using SABRE
Zeng, H., et al., Achieving 1% NMR polarization in water in less than 1min using SABRE. J Magn Reson, 2014. 246C(0): p. 119-121.
http://www.ncbi.nlm.nih.gov/pubmed/25123540
The application of novel Ir-NHC polarization transfer complexes by SABRE #DNPNMR #SABRE
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