BioNMR

BioNMR (http://www.bionmr.com/forum/)
-   News from NMR blogs (http://www.bionmr.com/forum/news-nmr-blogs-47/)
-   -   13C Dynamic Nuclear Polarization Using Derivatives of TEMPO Free Radical #DNPNMR (http://www.bionmr.com/forum/news-nmr-blogs-47/13c-dynamic-nuclear-polarization-using-derivatives-tempo-free-radical-dnpnmr-25255/)

nmrlearner 11-06-2017 05:23 PM

13C Dynamic Nuclear Polarization Using Derivatives of TEMPO Free Radical #DNPNMR
 
From The DNP-NMR Blog:

13C Dynamic Nuclear Polarization Using Derivatives of TEMPO Free Radical #DNPNMR

p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Niedbalski, P., et al., 13C Dynamic Nuclear Polarization Using Derivatives of TEMPO Free Radical. Appl. Magn. Reson., 2017. 48(9): p. 933-942.


https://doi.org/10.1007/s00723-017-0916-7


The nitroxide-based 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) free radical is widely used in 13C dynamic nuclear polarization (DNP) due to its relatively low cost, commercial availability, and effectiveness as polarizing agent. While a large number of TEMPO derivatives are available commercially, so far, only few have been tested for use in 13C DNP. In this study, we have tested and evaluated the 13C hyperpolarization efficiency of eight derivatives of TEMPO free radical with different side arms in the 4-position. In general, these TEMPO derivatives were found to have slight variations in efficiency as polarizing agents for DNP of 3 M [1-13C] acetate in 1:1 v/v ethanol:water at 3.35 T and 1.2 K. X-band electron paramagnetic resonance (EPR) spectroscopy revealed no significant differences in the spectral features among these TEMPO derivatives. 2H enrichment of the ethanol:water glassing matrix resulted in further improvement of the solid-state 13C DNP signals by factor of 2 to 2.5-fold with respect to the 13C DNP signal of non-deuterated DNP samples. These results suggest an interaction between the nuclear Zeeman reservoirs and the electron dipolar system via the thermal mixing mechanism.
p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica} p.p1 {margin: 0.0px 0.0px 0.0px 0.0px; font: 12.0px Helvetica}

Go to The DNP-NMR Blog for more info.


All times are GMT. The time now is 03:26 PM.

Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Search Engine Friendly URLs by vBSEO 3.6.0
Copyright, BioNMR.com, 2003-2013