Two demountable gyrotrons with internal mode converters were developded as sub-THz radiation sources for 700 MHz DNP (Dynamic Nuclear Polarization) enhanced NMR spectroscopy. Experimental study on the DNP-NMR spectroscopy will be carried out in Osaka University, Institute for Protein Research, as a collaboration with FIR UF. Both gyrotrons operate near 460 GHz and the output CW power measured at the end of transmission system made by circular waveguides is typically 20 to 30 watts. One of them named Gyrotron FU CW GVI (we are using “Gyrotron FU CW GO-1” as an official name in Osaka University) is designed to have a special function of high speed frequency modulation ?f within 100 MHz band. This will expand excitable band width of ESR and increase the number of electron spins contributing to DNP. The other gyrotron, Gyrotron FU CW GVIA (“Gyrotron FU CW GO-II”) has a function of frequency tunability ?f in the range of wider than 1.5 GHz, which is achieved in steady state by changing magnetic field intensity. This function should be used for adjusting the output frequency at the optimal value to achieve the highest enhancement factor of DNP.
[NMR paper] Application of NMR spectroscopy in the development of a biomimetic approach for hydrophobic drug association with physical hydrogels.
Application of NMR spectroscopy in the development of a biomimetic approach for hydrophobic drug association with physical hydrogels.
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Colloids Surf B Biointerfaces. 2013 Dec 19;115C:391-399
Authors: López-Cebral R, Martin-Pastor M, Paolicelli P, Casadei MA, Seijo B, Sanchez A
Abstract
The clinical application of sparingly soluble drugs is hampered by the wide range of problems associated to...
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Press Release: NIH Funds Development of Integrated THz System, Making DNP-NMR Spectroscopy More Affordable
From The DNP-NMR Blog:
Press Release: NIH Funds Development of Integrated THz System, Making DNP-NMR Spectroscopy More Affordable
Press Release
NIH Funds Development of Integrated THz System, Making DNP-NMR Spectroscopy More Affordable
Bridge12’s SBIR Fast-Track Grant Will Eliminate Need for Second Superconducting Magnet, Greatly Reducing Cost for Dynamic Nuclear Polarization
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11-21-2013 01:14 AM
High power THz technologies using high frequency gyrotrons
From the The DNP-NMR Blog:
High power THz technologies using high frequency gyrotrons
Idehara, T., et al. High power THz technologies using high frequency gyrotrons. in Infrared, Millimeter, and Terahertz Waves (IRMMW-THz), 2012 37th International Conference on. 2012.
http://dx.doi.org/10.1109/IRMMW-THz.2012.6380408
Development of 43Ca NMR Solid State NMR Spectroscopy as a Probe of Local Structure in Inorganic and Molecular Materials
Development of 43Ca NMR Solid State NMR Spectroscopy as a Probe of Local Structure in Inorganic and Molecular Materials
Publication year: 2012
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Danielle Laurencin, Mark E. Smith</br>
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Development of Non-Peptide Ligands of Growth Factor Receptor-Bound Protein 2-Src Homology 2 Domain Using Molecular Modeling and NMR Spectroscopy (†).
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J Med Chem. 2011 Jan 27;
Authors: Orcajo-Rinco?n AL, Ortega-Gutie?rrez S, Serrano P, Torrecillas IR, Wu?thrich K, Campillo M, Pardo L, Viso A, Benhamu? B, Lo?pez-Rodri?guez ML
We report a novel series of non-peptide ligands that inhibit the growth...
The Development of 460 GHz gyrotrons for 700 MHz DNP-NMR spectroscopy
Linear Mode
