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Eills, J., et al., Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems. J Magn Reson, 2017. 274: p. 163-172.
We have demonstrated two radiofrequency pulse methods which convert the nuclear singlet order of proton spin pairs into the magnetisation of nearby 13C nuclei. These irradiation schemes work well in the near-equivalence regime of the three-spin system, which applies when the difference in the two 1H-13C couplings is much smaller than the 1H-1H coupling. We use pulse sequences to generate thermally polarized singlet states in a reproducible manner, and study the singlet-to-magnetisation transfer step. Preliminary results demonstrate a parahydrogen-enhanced 13C polarization level of at least 9%, providing a signal enhancement factor of more than 9000, using 50% enriched parahydrogen.
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Singlet NMR Methodology in Two-Spin-1/2 Systems
Singlet NMR Methodology in Two-Spin-1/2 Systems
Publication date: Available online 1 December 2016
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Author(s): Giuseppe Pileio</br>
This paper discusses methodology developed over the past 12 years in order to access and manipulate singlet order in systems comprising two coupled spin-1/2 nuclei in liquid-state nuclear magnetic resonance. Pulse sequences that are valid for different regimes are discussed, and fully analytical proofs are given using different spin dynamics techniques that include...
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12-02-2016 07:45 AM
Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE
From The DNP-NMR Blog:
Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE
Olaru, A.M., et al., Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE. Chem Commun (Camb), 2016. 52(50): p. 7842-5.
http://www.ncbi.nlm.nih.gov/pubmed/27242264
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07-27-2016 09:20 PM
Singlet lifetime measurements in an all-proton chemically equivalent spin system by hyperpolarization and weak spin lock transfers
From The DNP-NMR Blog:
Singlet lifetime measurements in an all-proton chemically equivalent spin system by hyperpolarization and weak spin lock transfers
Zhang, Y., et al., Singlet lifetime measurements in an all-proton chemically equivalent spin system by hyperpolarization and weak spin lock transfers. Phys. Chem. Chem. Phys., 2015. 17(37): p. 24370-24375.
http://dx.doi.org/10.1039/C5CP03716F
The theory and practice of hyperpolarization in magnetic resonance using parahydrogen
The theory and practice of hyperpolarization in magnetic resonance using parahydrogen
Publication year: 2012
Source:Progress in Nuclear Magnetic Resonance Spectroscopy</br>
Richard A. Green, Ralph W. Adams, Simon B. Duckett, Ryan E. Mewis, David C. Williamson, Gary G.R. Green</br>
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03-15-2012 06:10 AM
Relaxation theory of nuclear singlet states in two spin-1/2 systems
Relaxation theory of nuclear singlet states in two spin-1/2 systems
Publication year: 2010
Source: Progress in Nuclear Magnetic Resonance Spectroscopy, Volume 56, Issue 3, April 2010, Pages 217-231</br>
Giuseppe*Pileio</br>
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Singlet order conversion and parahydrogen-induced hyperpolarization of 13C nuclei in near-equivalent spin systems
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