When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.
 

When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.

Related Articles When Less Is More: Combining Site-Specific Isotope Labeling and NMR Unravels Structural Details of Huntingtin Repeats.

Structure. 2020 Jul 07;28(7):730-732

Authors: Delhommel F, Sattler M

Abstract
In this issue of Structure, Urbanek et*al. (2020a) combine site-specific isotope labeling and NMR spectroscopy to investigate opposing effects of flanking regions onto the conformation of the poly-Q region in Huntingtin. Poly-Q interactions with preceding residues promote an ?-helical conformation while a following proline-rich region favors extended conformations.


PMID: 32640252 [PubMed - in process]



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