In vitro NMR proton T1 measurements in peritoneal ascites.
 

In vitro NMR proton T1 measurements in peritoneal ascites.

http://www.ncbi.nlm.nih.gov/corehtml...med-iop-ej.gif Related Articles In vitro NMR proton T1 measurements in peritoneal ascites.

Phys Med Biol. 1996 Mar;41(3):539-49

Authors: Yilmaz A, Tez M, Göral V, Boylu S, Kaplan A, Kavak G

The proton spin-lattice relaxation rate (1/T1) in malignant and non-malignant ascites was measured with an FT NMR spectrometer operating at 60 MHz. The mean relaxation rate in non-malignant ascites was significantly smaller than that of malignant ascites. However, the 1/T1 of malignant ascites overlaps with that of non-malignant ascites over all concentrations of total protein (TP) in samples. The 1/T1 in non-malignant ascites correlates strongly with TP, whilst the 1/T1 in malignant ascites shows only a moderate correlation. T1 measurements before and after addition of ascorbic acid (reductant) suggest that there is a small paramagnetic contribution of ions to the 1/T1 in malignant ascites. The least-squares fitting of 1/T1 versus TP for non-malignant data gives a linear relationship, and suggests that the T1 mechanism in non-malignant ascites is caused by a fast chemical exchange of water molecules between protein-bound water and free water.

PMID: 8778831 [PubMed - indexed for MEDLINE]



Source: PubMed