Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.
 

Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.

http://www.bionmr.com//www.ncbi.nlm....ed-acspubs.jpg Related Articles Targeted Molecular Imaging of Cancer Cells Using MS2-Based (129)Xe NMR.

Bioconjug Chem. 2016 Aug 17;27(8):1796-801

Authors: Jeong K, Netirojjanakul C, Munch HK, Sun J, Finbloom JA, Wemmer DE, Pines A, Francis MB

Abstract
We have synthesized targeted, selective, and highly sensitive (129)Xe NMR nanoscale biosensors using a spherical MS2 viral capsid, Cryptophane A molecules, and DNA aptamers. The biosensors showed strong binding specificity toward targeted lymphoma cells (Ramos line). Hyperpolarized (129)Xe NMR signal contrast and hyper-CEST (129)Xe MRI image contrast indicated its promise as highly sensitive hyperpolarized (129)Xe NMR nanoscale biosensor for future applications in cancer detection in vivo.


PMID: 27454679 [PubMed - indexed for MEDLINE]



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