Related ArticlesStructural genomics and the metabolome: combining computational and NMR methods to identify target ligands.
Curr Opin Drug Discov Devel. 2004 Jan;7(1):62-8
Authors: Parsons L, Orban J
One of the goals of structural genomics is to use three-dimensional structures to gain insights into the function of poorly understood or hypothetical proteins. Approximate functions are often apparent from the protein fold, but more precise biochemical functions are difficult to obtain from the structure alone. Analysis of the structure using a variety of informatics tools can lead to the identification of possible binding sites for small molecules. This knowledge can be used in combination with molecular docking and nuclear magnetic resonance screening methods to identify candidate target ligands for proteins of previously unknown function.
[NMR900 blog] ICSG 2011: International Conference on Structural Genomics
ICSG 2011: International Conference on Structural Genomics
Dear Colleague, We hope that you are planning to join us in Toronto, Canada for the International Conference on Structural Genomics 2011 which will be held on May 10-14, 2011. We have an excellent scientific program prepared which includes both oral and poster presentations (scientific program). Participants will also enjoy the fabulous view of the city of Toronto during the banquet to be held at the revolving 360 Restaurant at the top of the CN tower. An optional post-conference tour to Niagara Falls will also be available. We...
nmrlearner
News from NMR blogs
0
04-06-2011 11:00 PM
International Conference on Structural Genomics 2011
International Conference on Structural Genomics 2011
Dear Colleagues,
We are pleased to announce that registration is now open for the International Conference on Structural Genomics 2011, which will be held in Toronto, Canada on May 10-14, 2011. This meeting is the 6th in this series of biennial meetings of the International Structural Genomics Organization. The meeting is designed to serve as a forum to discuss the most recent developments in structural genomics, structural/chemical biology, and their impact on research in biology, medicine and disease. A substantial number of short...
nmrlearner
Conferences
0
11-27-2010 07:34 AM
[NMR paper] NMR and structural genomics.
NMR and structural genomics.
Related Articles NMR and structural genomics.
Acc Chem Res. 2003 Mar;36(3):207-14
Authors: Staunton D, Owen J, Campbell ID
The role of NMR in structural genomics is outlined, with particular emphasis on using protein domains as targets. Strategies for domain expression, characterization, and labeling are presented.
nmrlearner
Journal club
0
11-24-2010 09:01 PM
[NMR paper] Protein NMR spectroscopy in structural genomics.
Protein NMR spectroscopy in structural genomics.
Related Articles Protein NMR spectroscopy in structural genomics.
Nat Struct Biol. 2000 Nov;7 Suppl:982-5
Authors: Montelione GT, Zheng D, Huang YJ, Gunsalus KC, Szyperski T
Protein NMR spectroscopy provides an important complement to X-ray crystallography for structural genomics, both for determining three-dimensional protein structures and in characterizing their biochemical and biophysical functions.
nmrlearner
Journal club
0
11-19-2010 08:29 PM
[NMR paper] Computational methods for determining protein structures from NMR data.
Computational methods for determining protein structures from NMR data.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles Computational methods for determining protein structures from NMR data.
Biochem Pharmacol. 1990 Jul 1;40(1):15-22
Authors: Gippert GP, Yip PF, Wright PE, Case DA
The general procedures by which solution structures of proteins may be deduced from distance and angular constraints derived from NMR are reviewed, with an emphasis on practical aspects of...
nmrlearner
Journal club
0
08-21-2010 10:48 PM
Combining NMR and EPR Methods for Homodimer Protein Structure Determination.
Combining NMR and EPR Methods for Homodimer Protein Structure Determination.
Related Articles Combining NMR and EPR Methods for Homodimer Protein Structure Determination.
J Am Chem Soc. 2010 Aug 10;
Authors: Yang Y, Ramelot TA, McCarrick RM, Ni S, Feldmann EA, Cort JR, Wang H, Ciccosanti C, Jiang M, Janjua H, Acton TB, Xiao R, Everett JK, Montelione GT, Kennedy MA
There is a general need to develop more powerful and more robust methods for structural characterization of homodimers, homo-oligomers, and multiprotein complexes using...
nmrlearner
Journal club
0
08-17-2010 03:36 AM
Combining methods for speeding up multi-dimensional acquisition. Sparse sampling and
Combining methods for speeding up multi-dimensional acquisition. Sparse sampling and fast pulsing methods for unfolded proteins
Publication year: 2010
Source: Journal of Magnetic Resonance, In Press, Accepted Manuscript, Available online 12 June 2010</br>
Dominique, Marion</br>
Resonance assignment of intrinsically disordered proteins is made difficult by the extensive spectral overlaps. High-resolution 3D and 4D spectra are thus essential for this purpose. We have adapted the series of 3D BEST experiments proposed by Lescop et al to the case of unfolded proteins. Longer acquisitions...
nmrlearner
Journal club
0
08-16-2010 03:50 AM
Combining NMR and EPR Methods for Homodimer Protein Structure Determination
http://pubs.acs.org//appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja105080h/aop/images/medium/ja-2010-05080h_0003.gif
Combining NMR and EPR Methods for Homodimer Protein Structure Determination
There is a general need to develop more powerful and more robust methods for structural characterization of homodimers, homo-oligomers, and multiprotein complexes using solution-state NMR methods. In recent years, there has been increasing emphasis on integrating distinct and complementary methodologies for structure determination of multiprotein ...
Structural genomics and the metabolome: combining computational and NMR methods to id
Linear Mode
