Structural biology of RNA-binding proteins in the context of phase separation: What NMR and EPR can bring?
 

Structural biology of RNA-binding proteins in the context of phase separation: What NMR and EPR can bring?

Liquid-liquid phase separation of RNA-binding proteins underlies the formation of membraneless organelles, whose composition is dynamic and whose existence may be transient. These organelles are involved in regulation of RNA processing and translation and, if they behave abnormally, in pathologies. Because disorder phenomena are essential in their formation and dynamics, established methodology is insufficient for characterizing their structure. In this review, we consider the current and...

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