A Step Towards NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods
 

A Step Towards NRF2-DNA Interaction Inhibitors by Fragment-Based NMR Methods

The NRF2 transcription factor is a key regulator in cellular oxidative stress response, and acts as a tumor suppressor. Aberrant activation of NRF2 has been implicated in promoting chemo-resistance, tumor growth, and metastasis by activating its downstream target genes. Hence, inhibition of NRF2 promises to be an attractive therapeutic strategy to suppress cell proliferation and enhance cell apoptosis in cancer. Direct targeting of NRF2 with small-molecules to discover protein-DNA inhibitors is...

More...