Solution NMR backbone assignment of the SASH1 SLy proteins associated disordered region (SPIDER)
 

Solution NMR backbone assignment of the SASH1 SLy proteins associated disordered region (SPIDER)

SASH1 is a scaffold protein with context-dependent biological functions in cell adhesion, tumor metastasis, lung development, and pigmentation. As a member of the SLy protein family, it contains the conserved SLY, SH3, and SAM domains. The 19 kDa SLY domain harbors over 70% of the SASH1 variants associated with pigmentation disorders. However, its solution structure or dynamics have not been investigated yet, and its exact position in the sequence is not clearly defined. Based on the...

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