Solid-State NMR of PEGylated Proteins.
 

Solid-State NMR of PEGylated Proteins.

Related Articles Solid-State NMR of PEGylated Proteins.

Angew Chem Int Ed Engl. 2016 Jan 12;

Authors: Ravera E, Ciambellotti S, Cerofolini L, Martelli T, Kozyreva T, Bernacchioni C, Giuntini S, Fragai M, Turano P, Luchinat C

Abstract
PEGylated proteins are widely used in biomedicine but, in spite of their importance, no atomic-level information is available since they are generally resistant to structural characterization approaches. PEGylated proteins are shown here to yield highly resolved solid-state NMR spectra, which allows assessment of the structural integrity of proteins when PEGylated for therapeutic or diagnostic use.


PMID: 26756539 [PubMed - as supplied by publisher]



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