Aggregation of the tau protein into fibrillar cross-? aggregates is a hallmark of Alzheimer's diseases (AD) and many other neurodegenerative tauopathies. Recently, several core structures of patient-derived tau paired helical filaments (PHFs) have been solved revealing a structural variability that often correlates with a specific tauopathy. To further characterize the dynamics of these fibril cores, to screen for strain-specific small molecules as potential biomarkers and therapeutics, and to...
Cytoskeletal-like Filaments of Ca2+-Calmodulin-DependentProtein Kinase II Are Formed in a Regulated and Zn2+-DependentManner
Cytoskeletal-like Filaments of Ca2+-Calmodulin-DependentProtein Kinase II Are Formed in a Regulated and Zn2+-DependentManner
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/bichaw/0/bichaw.ahead-of-print/acs.biochem.7b00028/20170324/images/medium/bi-2017-000282_0014.gif
Biochemistry
DOI: 10.1021/acs.biochem.7b00028
http://feeds.feedburner.com/~ff/acs/bichaw?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/bichaw/~4/8GCbdsJK7Mk
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03-25-2017 12:02 PM
ssNMR structure of helical filaments [Biophysics and Computational Biology]
ssNMR structure of helical filaments
He, L., Bardiaux, B., Ahmed, M., Spehr, J., Konig, R., Lunsdorf, H., Rand, U., Luhrs, T., Ritter, C....
Date: 2016-01-19
The controlled formation of filamentous protein complexes plays a crucial role in many biological systems and represents an emerging paradigm in signal transduction. The mitochondrial antiviral signaling protein (MAVS) is a central signal transduction hub in innate immunity that is activated by a receptor-induced conversion into helical superstructures (filaments) assembled... Read More
PNAS:
Number: 3
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01-20-2016 09:01 AM
[NMR paper] Structure determination of helical filaments by solid-state NMR spectroscopy.
Structure determination of helical filaments by solid-state NMR spectroscopy.
Related Articles Structure determination of helical filaments by solid-state NMR spectroscopy.
Proc Natl Acad Sci U S A. 2016 Jan 5;
Authors: He L, Bardiaux B, Ahmed M, Spehr J, König R, Lünsdorf H, Rand U, Lührs T, Ritter C
Abstract
The controlled formation of filamentous protein complexes plays a crucial role in many biological systems and represents an emerging paradigm in signal transduction. The mitochondrial antiviral signaling protein (MAVS) is a...
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01-07-2016 11:10 PM
[NMR paper] ?-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR.
?-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR.
?-Helical architecture of cytoskeletal bactofilin filaments revealed by solid-state NMR.
Proc Natl Acad Sci U S A. 2014 Dec 30;
Authors: Vasa S, Lin L, Shi C, Habenstein B, Riedel D, Kühn J, Thanbichler M, Lange A
Abstract
Bactofilins are a widespread class of bacterial filament-forming proteins, which serve as cytoskeletal scaffolds in various cellular pathways. They are characterized by a conserved architecture, featuring a central...
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01-01-2015 11:00 PM
[NMR paper] Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state NMR.
Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state NMR.
Related Articles Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state NMR.
Biochemistry. 2014 Oct 3;
Authors: Hoop CL, Lin HK, Kar K, Hou Z, Poirier MA, Wetzel R, van der Wel PC
Abstract
In Huntington's Disease (HD), expansion of a polyglutamine (polyQ) domain in the huntingtin (htt) protein leads to misfolding and aggregation....
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?-Sheet Coreof Tau Paired Helical FilamentsRevealed by Solid-State NMR
?-Sheet Coreof Tau Paired Helical FilamentsRevealed by Solid-State NMR
Venita Daebel, Subashchandrabose Chinnathambi, Jacek Biernat, Martin Schwalbe, Birgit Habenstein, Antoine Loquet, Elias Akoury, Katharina Tepper, Henrik Mu?ller, Marc Baldus, Christian Griesinger, Markus Zweckstetter, Eckhard Mandelkow, Vinesh Vijayan and Adam Lange
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja305470p/aop/images/medium/ja-2012-05470p_0008.gif
Journal of the American Chemical Society
DOI: 10.1021/ja305470p...
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The Core of Ure2p Prion Fibrils Is Formed by the N-Terminal Segment in a Parallel Cross-? Structure: Evidence from Solid-State NMR.
The Core of Ure2p Prion Fibrils Is Formed by the N-Terminal Segment in a Parallel Cross-? Structure: Evidence from Solid-State NMR.
The Core of Ure2p Prion Fibrils Is Formed by the N-Terminal Segment in a Parallel Cross-? Structure: Evidence from Solid-State NMR.
J Mol Biol. 2011 Apr 8;
Authors: Kryndushkin DS, Wickner RB, Tycko R
Intracellular fibril formation by Ure2p produces the non-Mendelian genetic element in Saccharomyces cerevisiae, making Ure2p a prion protein. We show that solid-state NMR spectra of full-length Ure2p fibrils, seeded...
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04-19-2011 11:01 PM
[NMR paper] High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments.
High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments.
Related Articles High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments.
J Am Chem Soc. 2005 Jul 27;127(29):10138-9
Authors: Sillen A, Wieruszeski JM, Leroy A, Younes AB, Landrieu I, Lippens G
HRMAS NMR of tau paired helical fragments assembled with heparin show an intensity decrease for those amino acids that are incorporated into the rigid core...
Solid-state NMR of paired helical filaments formed by the core tau fragment tau(297-391)
Linear Mode
