Small molecule induced toxic human-IAPP species characterized by NMR.
 

Small molecule induced toxic human-IAPP species characterized by NMR.

Small molecule induced toxic human-IAPP species characterized by NMR.

Chem Commun (Camb). 2020 Oct 02;:

Authors: Cox SJ, Rodriguez Camargo DC, Lee YH, Dubini RCA, Rovó P, Ivanova MI, Padmini V, Reif B, Ramamoorthy A

Abstract
In this study, the effect of CurDAc, a water-soluble curcumin derivative, on the formation and stability of amyloid fibers is revealed. CurDAc interaction with amyloid is structurally selective, which is reflected in a strong interference with hIAPP aggregation while showing weaker interactions with human-calcitonin and amyloid-?1-40 in comparison. Remarkably, CurDAc also exhibited potent fiber disaggregation for hIAPP generating a toxic oligomeric species.


PMID: 33006345 [PubMed - as supplied by publisher]



More...