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-   -   [NMR paper] Site-specific identification of an a? fibril-heparin interaction site by using solid-state NMR spectroscopy. (http://www.bionmr.com/forum/journal-club-9/site-specific-identification-fibril-heparin-interaction-site-using-solid-state-nmr-spectroscopy-18367/)

nmrlearner 06-12-2013 11:42 AM

Site-specific identification of an a? fibril-heparin interaction site by using solid-state NMR spectroscopy.
 
Site-specific identification of an a? fibril-heparin interaction site by using solid-state NMR spectroscopy.

http://www.bionmr.com//www.ncbi.nlm....x_FullText.gif Related Articles Site-specific identification of an a? fibril-heparin interaction site by using solid-state NMR spectroscopy.

Angew Chem Int Ed Engl. 2012 Dec 21;51(52):13140-3

Authors: Madine J, Pandya MJ, Hicks MR, Rodger A, Yates EA, Radford SE, Middleton DA

Abstract
At the surface of A?(1-40) amyloid fibrils that have a threefold molecular symmetry (green in the left picture) a site of interaction of the glycosaminoglycan analogue heparin (blue) was identified. The binding site consists of residues at the N terminus and the turn regions defining the apices of the triangular geometry. Heparin has a lower affinity for A?(1-40) fibrils having twofold molecular symmetry, thus revealing a remarkable morphological selectivity.


PMID: 23161730 [PubMed - indexed for MEDLINE]



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