Side-Chain Dynamics of the ?1B -Adrenergic Receptor determined by NMR via Methyl Relaxation
 

Side-Chain Dynamics of the ?1B -Adrenergic Receptor determined by NMR via Methyl Relaxation

G protein-coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (~?s-ms). On a faster timescale (~ps-ns), the conformational landscape of GPCRs is governed by the rapid dynamics of amino acid side chains. Such dynamics are essential for protein functions such as ligand recognition and allostery. Unfortunately, technical challenges have almost entirely precluded the...

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