Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR
 

Sequence requirements of the FFAT-like motif for specific binding to VAP-A are revealed by NMR

The endoplasmic reticulum transmembrane protein vesicle-associated membrane protein-associated protein (VAP) plays a central role in the formation and function of membrane contact sites (MCS) through its interactions with proteins. The major sperm protein (MSP) domain of VAP binds to a variety of sequences which are referred to as FFAT-like motifs. In this study, we investigated the interactions of eight peptides containing FFAT-like motifs with the VAP-A MSP domain (VAP-A(MSP) ) by solution...

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