[NMR paper] Salecan protected against concanavalin A-induced acute liver injury by modulating T cell immune responses and NMR-based metabolic profiles.
Related ArticlesSalecan protected against concanavalin A-induced acute liver injury by modulating T cell immune responses and NMR-based metabolic profiles.
Toxicol Appl Pharmacol. 2017 Feb 15;317:63-72
Authors: Sun Q, Xu X, Yang X, Weng D, Wang J, Zhang J
Abstract
Salecan, a water-soluble extracellular ?-glucan produced by Agrobacterium sp. ZX09, has been reported to exhibit a wide range of biological effects. The aims of the present study were to investigate the protective effect of salecan against Concanavalin A (ConA)-induced hepatitis, a well-established animal model of immune-mediated liver injury, and to search for possible mechanisms. C57BL/6 mice were pretreated with salecan followed by ConA injection. Salecan treatment significantly reduced ConA-induced acute liver injury, and suppressed the expression and secretion of inflammatory cytokines including interferon (IFN)-?, interleukin (IL)-6 and IL-1? in ConA-induced liver injury model. The high expression levels of chemokines and adhesion molecules such as MIP-1?, MIP-1?, ICAM-1, MCP-1 and RANTES in the liver induced by ConA were also down-regulated after salecan treatment. Salecan inhibited the infiltration and activation of inflammatory cells, especially T cells, in the liver induced by ConA. Moreover, salecan reversed the metabolic profiles of ConA-treated mice towards the control group by partly recovering the metabolic perturbations induced by ConA. Our results suggest the preventive and therapeutic potential of salecan in immune-mediated hepatitis.
Fumarase activity: an in vivo and in vitro biomarker for acute kidney injury
From The DNP-NMR Blog:
Fumarase activity: an in vivo and in vitro biomarker for acute kidney injury
p.p1 {margin: 0.0px 0.0px 0.0px 36.0px; text-indent: -36.0px; font: 12.0px Helvetica}
Nielsen, P.M., et al., Fumarase activity: an in vivo and in vitro biomarker for acute kidney injury. Scientific Reports, 2017. 7: p. 40812.
http://dx.doi.org/10.1038/srep40812
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05-09-2017 12:37 AM
[NMR paper] The effects of acute lipopolysaccharide challenge on dairy goat liver metabolism assessed with (1) HNMR metabonomics.
The effects of acute lipopolysaccharide challenge on dairy goat liver metabolism assessed with (1) HNMR metabonomics.
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J Anim Physiol Anim Nutr (Berl). 2016 Feb 5;
Authors: Wang LF, Jia SD, Yang GQ, Liu RY, Yang GY, Li M, Zhu HS, Wang YY, Han LQ
Abstract
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02-06-2016 03:10 PM
[NMR paper] Metabolic responses during hemodialysis determined by quantitative (1)H NMR spectroscopy.
Metabolic responses during hemodialysis determined by quantitative (1)H NMR spectroscopy.
Metabolic responses during hemodialysis determined by quantitative (1)H NMR spectroscopy.
J Pharm Biomed Anal. 2015 Apr 7;111:159-162
Authors: Fujiwara M, Ando I, Takeuchi K, Oguma S, Sato H, Sekino H, Sato K, Imai Y
Abstract
A large proportion of patients with end-stage renal disease have lifelong hemodialysis (HD) treatment. HD rapidly and indiscriminately removes necessary small metabolites together with uremic toxins from plasma...
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04-18-2015 11:39 AM
[NMR paper] Pea Fiber and Wheat Bran Fiber Show Distinct Metabolic Profiles in Rats as Investigated by a 1H NMR-Based Metabolomic Approach.
Pea Fiber and Wheat Bran Fiber Show Distinct Metabolic Profiles in Rats as Investigated by a 1H NMR-Based Metabolomic Approach.
Pea Fiber and Wheat Bran Fiber Show Distinct Metabolic Profiles in Rats as Investigated by a 1H NMR-Based Metabolomic Approach.
PLoS One. 2014;9(12):e115561
Authors: Liu G, Xiao L, Fang T, Cai Y, Jia G, Zhao H, Wang J, Chen X, Wu C
Abstract
This study aimed to examine the effect of pea fiber (PF) and wheat bran fiber (WF) supplementation in rat metabolism. Rats were assigned randomly to one of three...
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12-30-2014 03:28 PM
[NMR paper] Changes in metabolic markers in insulin-producing ?-cells during hypoxia-induced cell death as studied by NMR metabolomics.
Changes in metabolic markers in insulin-producing ?-cells during hypoxia-induced cell death as studied by NMR metabolomics.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--pubs.acs.org-images-pubmed-acspubs.jpg Related Articles Changes in metabolic markers in insulin-producing ?-cells during hypoxia-induced cell death as studied by NMR metabolomics.
J Proteome Res. 2013 Aug 2;12(8):3738-45
Authors: Tian L, Kim HS, Kim H, Jin X, Jung HS, Park KS, Cho KW, Park S, Moon WK
Abstract
This study was designed to investigate...
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02-19-2014 12:07 AM
[NMR paper] Studies of single-walled carbon nanotube-induced hepatotoxicity by NMR-based metabonomics of rat blood plasma and liver extracts.
Studies of single-walled carbon nanotube-induced hepatotoxicity by NMR-based metabonomics of rat blood plasma and liver extracts.
Studies of single-walled carbon nanotube-induced hepatotoxicity by NMR-based metabonomics of rat blood plasma and liver extracts.
Nanoscale Res Lett. 2013 May 16;8(1):236
Authors: Lin B, Zhang H, Lin Z, Fang Y, Tian L, Yang H, Yan J, Liu H, Zhang W, Xi Z
Abstract
The toxicological effects of single-walled carbon nanotubes (SWCNTs) were investigated after intratracheal instillation in male Wistar rats over...
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Lanthanide-Based NMR:A Tool To Investigate ComponentDistribution in Mixed-Monolayer-Protected Nanoparticles
Lanthanide-Based NMR:A Tool To Investigate ComponentDistribution in Mixed-Monolayer-Protected Nanoparticles
Gaetano Guarino, Federico Rastrelli, Paolo Scrimin and Fabrizio Mancin
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/ja211030y/aop/images/medium/ja-2011-11030y_0004.gif
Journal of the American Chemical Society
DOI: 10.1021/ja211030y
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/sxi7awc7HY8
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Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics.
Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics.
Metabolic profiling of cadmium-induced effects in one pioneer intertidal halophyte Suaeda salsa by NMR-based metabolomics.
Ecotoxicology. 2011 May 15;
Authors: Liu X, Yang C, Zhang L, Li L, Liu S, Yu J, You L, Zhou D, Xia C, Zhao J, Wu H
Cadmium is a non-essential element to living organisms and has become the severe contaminant in both seawater and sediment in the intertidal zones of the Bohai Sea. The halophyte, Suaeda salsa...
Salecan protected against concanavalin A-induced acute liver injury by modulating T cell immune responses and NMR-based metabolic profiles.
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