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Default Ribosome-Amplified Metabolism, RAMBO, Measured by NMR Spectroscopy

Ribosome-Amplified Metabolism, RAMBO, Measured by NMR Spectroscopy

NMR spectroscopy was used to investigate the phenomenon of ribosome-amplified metabolism or RAMBO between pyruvate kinase and ribosomes. Because the concentration of ribosomes increases as the cell grows, ribosome binding interactions may regulate metabolic fluxes by altering the distribution of bound and free enzymes. Pyruvate kinase (PK) catalyzes the last step of glycolysis and represents a major drug target for controlling bacterial infections. The binding of metabolic enzymes to ribosomes...

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