Protein structure prediction using residue-resolved protection factors from hydrogen-deuterium exchange NMR
 

Protein structure prediction using residue-resolved protection factors from hydrogen-deuterium exchange NMR

Hydrogen-deuterium exchange (HDX) measured by nuclear magnetic resonance (NMR) provides structural information for proteins relating to solvent accessibility and flexibility. While this structural information is beneficial, the data cannot be used exclusively to elucidate structures. However, the structural information provided by the HDX-NMR data can be supplemented by computational methods. In previous work, we developed an algorithm in Rosetta to predict structures using qualitative HDX-NMR...

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