Protein-Protein Connections-Oligomer, Amyloid and Protein Complex-By Wide Line (1)H NMR
 

Protein-Protein Connections-Oligomer, Amyloid and Protein Complex-By Wide Line (1)H NMR

The amount of bonds between constituting parts of a protein aggregate were determined in wild type (WT) and A53T ?-synuclein (?S) oligomers, amyloids and in the complex of thymosin-?(4)-cytoplasmic domain of stabilin-2 (T?(4)-stabilin CTD). A53T ?S aggregates have more extensive ?sheet contents reflected by constant regions at low potential barriers in difference (to monomers) melting diagrams (MDs). Energies of the intermolecular interactions and of secondary structures bonds, formed during...

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