Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy [Biophysics and Computational Biology]
 

Probing the cooperativity of Thermoplasma acidophilum proteasome core particle gating by NMR spectroscopy [Biophysics and Computational Biology]

Rui Huang, Felipe Perez, Lewis E. Kay...
Date: 2017-11-14

The 20S proteasome core particle (20S CP) plays an integral role in cellular homeostasis by degrading proteins no longer required for function. The process is, in part, controlled via gating residues localized to the ends of the heptameric barrel-like CP structure that occlude substrate entry pores, preventing unregulated degradation of... Read More


PNAS:
Number: 46
Volume: 114