Developments in solution NMR spectroscopy have significantly impacted the biological questions that can now be addressed by this methodology. By means of illustration, we present here a perspective focusing on studies of a number of molecular machines that are critical for cellular homeostasis. The role of NMR in elucidating the structural dynamics of these important molecules is emphasized, focusing specifically on intersubunit allosteric communication in homo-oligomers. In many biophysical...
Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR spectroscopy [Biophysics and Computational Biology]
Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR spectroscopy
Yuki Toyama, Lewis E. Kay...
Date: 2021-12-10
Developments in solution NMR spectroscopy have significantly impacted the biological questions that can now be addressed by this methodology. By means of illustration, we present here a perspective focusing on studies of a number of molecular machines that are critical for cellular homeostasis. The role of NMR in elucidating the... Read More
PNAS:
Number: 50
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SolutionNMR Spectroscopy Provides an Avenue for theStudy of Functionally Dynamic Molecular Machines: The Example of ProteinDisaggregation
SolutionNMR Spectroscopy Provides an Avenue for theStudy of Functionally Dynamic Molecular Machines: The Example of ProteinDisaggregation
Rina Rosenzweig and Lewis E. Kay
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.5b11346/20151229/images/medium/ja-2015-11346t_0005.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.5b11346
http://feeds.feedburner.com/~ff/acs/jacsat?d=yIl2AUoC8zA
http://feeds.feedburner.com/~r/acs/jacsat/~4/A6ElDNtUQ-g
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[NMR paper] Solution NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation.
Solution NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation.
Solution NMR Spectroscopy Provides an Avenue for the Study of Functionally Dynamic Molecular Machines: The Example of Protein Disaggregation.
J Am Chem Soc. 2015 Dec 11;
Authors: Rosenzweig R, Kay LE
Abstract
Solution-based NMR spectroscopy has been an important tool for studying the structure and dynamics of relatively small proteins and protein complexes with aggregate molecular masses...
Visualizing Specific Cross-Protomer Interactions in the Homo-Oligomeric Membrane Protein Proteorhodopsin by Dynamic-Nuclear-Polarization-Enhanced Solid-State NMR
Visualizing Specific Cross-Protomer Interactions in the Homo-Oligomeric Membrane Protein Proteorhodopsin by Dynamic-Nuclear-Polarization-Enhanced Solid-State NMR
Jakob Maciejko, Michaela Mehler, Jagdeep Kaur, Tobias Lieblein, Nina Morgner, Olivier Ouari, Paul Tordo, Johanna Becker-Baldus and Clemens Glaubitz
http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/0/jacsat.ahead-of-print/jacs.5b03606/20150713/images/medium/ja-2015-03606j_0008.gif
Journal of the American Chemical Society
DOI: 10.1021/jacs.5b03606
...
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[NMR paper] Visualizing specific Cross-Protomer Interactions in the Homo-Oligomeric Membrane Protein Proteorhodopsin by DNP-enhanced Solid-state NMR.
Visualizing specific Cross-Protomer Interactions in the Homo-Oligomeric Membrane Protein Proteorhodopsin by DNP-enhanced Solid-state NMR.
Visualizing specific Cross-Protomer Interactions in the Homo-Oligomeric Membrane Protein Proteorhodopsin by DNP-enhanced Solid-state NMR.
J Am Chem Soc. 2015 Jun 23;
Authors: Maciejko J, Mehler M, Kaur J, Lieblein T, Morgner N, Ouari O, Tordo P, Becker-Baldus J, Glaubitz C
Abstract
Membrane proteins often form oligomeric complexes within the lipid bilayer but factors controlling their assembly...
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[NMR paper] Systematic solution to homo-oligomeric structures determined by NMR.
Systematic solution to homo-oligomeric structures determined by NMR.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--media.wiley.com-assets-2250-98-WileyOnlineLibrary-Button_120x27px_FullText.gif Related Articles Systematic solution to homo-oligomeric structures determined by NMR.
Proteins. 2015 Jan 23;
Authors: Martin JW, Zhou P, Donald BR
Abstract
Protein structure determination by NMR has predominantly relied on simulated annealing-based conformational search for a converged fold using primarily...
Probing allosteric interactions in homo-oligomeric molecular machines using solution NMR spectroscopy
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