Probing allosteric coupling in a constitutively open mutant of the ion channel KcsA using solid-state NMR [Biophysics and Computational Biology]
 

Probing allosteric coupling in a constitutively open mutant of the ion channel KcsA using solid-state NMR [Biophysics and Computational Biology]

Zhiyu Sun, Yunyao Xu, Dongyu Zhang, Ann E. McDermott...
Date: 2020-03-31

Transmembrane allosteric coupling is a feature of many critical biological signaling events. Here we test whether transmembrane allosteric coupling controls the potassium binding affinity of the prototypical potassium channel KcsA in the context of C-type inactivation. Activation of KcsA is initiated by proton binding to the pH gate upon an... Read More


PNAS:
Number: 13
Volume: 117