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-   -   [NMR paper] pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy. (http://www.bionmr.com/forum/journal-club-9/ph-dependent-thermodynamic-intermediates-phlip-membrane-insertion-determined-solid-state-nmr-spectroscopy-26592/)

nmrlearner 04-23-2019 07:54 PM

pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy.
 
pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy.

http://www.bionmr.com//www.ncbi.nlm....-pnas_full.gif Related Articles pH-dependent thermodynamic intermediates of pHLIP membrane insertion determined by solid-state NMR spectroscopy.

Proc Natl Acad Sci U S A. 2018 11 27;115(48):12194-12199

Authors: Otieno SA, Hanz SZ, Chakravorty B, Zhang A, Klees LM, An M, Qiang W


Abstract
The applications of the pH low insertion peptide (pHLIP) in cancer diagnosis and cross-membrane cargo delivery have drawn increasing attention in the past decade. With its origin as the transmembrane (TM) helix C of bacteriorhodopsin, pHLIP is also an important model for understanding how pH can affect the folding and topogenesis of a TM ?-helix. Protonations of multiple D/E residues transform pHLIP from an unstructured coil at membrane surface (known as state II, at pH >= 7) to a TM ?-helix (state III, pH


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