Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR [Biophysics and Computational Biology]
 

Oligomeric assembly regulating mitochondrial HtrA2 function as examined by methyl-TROSY NMR [Biophysics and Computational Biology]

Yuki Toyama, Robert W. Harkness, Tim Y. T. Lee, Jason T. Maynes, Lewis E. Kay...
Date: 2021-03-10

Human High temperature requirement A2 (HtrA2) is a mitochondrial protease chaperone that plays an important role in cellular proteostasis and in regulating cell-signaling events, with aberrant HtrA2 function leading to neurodegeneration and parkinsonian phenotypes. Structural studies of the enzyme have established a trimeric architecture, comprising three identical protomers in which... Read More


PNAS:
Number: 11
Volume: 118