NOAH-(15N/13C)-CEST NMR supersequence for dynamics studies of biomolecules
 

NOAH-(15N/13C)-CEST NMR supersequence for dynamics studies of biomolecules

An NMR supersequence is introduced for the rapid acquisition of ^(15)N-CEST and methyl-^(13)C-CEST experiments in the same pulse sequence for applications to proteins. The high sensitivity and accuracy allows the simultaneous quantitative characterization of backbone and side-chain dynamics on the millisecond timescale ideal for routine screening for alternative protein states.

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