BioNMR

BioNMR (http://www.bionmr.com/forum/)
-   Journal club (http://www.bionmr.com/forum/journal-club-9/)
-   -   [NMR paper] NMR techniques for characterization of ligand binding: utility for lead generation an (http://www.bionmr.com/forum/journal-club-9/nmr-techniques-characterization-ligand-binding-utility-lead-generation-5430/)

nmrlearner 08-21-2010 04:03 PM

NMR techniques for characterization of ligand binding: utility for lead generation an
 
NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery.

http://www.ncbi.nlm.nih.gov/corehtml...ogo_120x27.gif Related Articles NMR techniques for characterization of ligand binding: utility for lead generation and optimization in drug discovery.

Biopolymers. 1999;51(3):221-43

Authors: Moore JM

Over the last ten years, nmr spectroscopy has evolved into an important discipline in drug discovery. Initially, nmr was most useful as a technique to provide structural information regarding protein drug targets and target-ligand interactions. More recently, it has been shown that nmr may be used as an alternative method for identification of small molecule ligands that bind to protein drug targets. High throughput implementation of these experiments to screen small molecule libraries may lead to identification of potent and novel lead compounds. In this review, we will use examples from our own research to illustrate how nmr experiments to characterize ligand binding may be used to both screen for novel compounds during the process of lead generation, as well as provide structural information useful for lead optimization during the latter stages of a discovery program.

PMID: 10516573 [PubMed - indexed for MEDLINE]



Source: PubMed


All times are GMT. The time now is 10:43 AM.

Powered by vBulletin® Version 3.7.3
Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.
Search Engine Friendly URLs by vBSEO 3.6.0
Copyright, BioNMR.com, 2003-2013