Related ArticlesNMR Studies of the Structure and Function of the HIV-1 5'-Leader.
Viruses. 2016 Dec 21;8(12):
Authors: Keane SC, Summers MF
Abstract
The 5'-leader of the human immunodeficiency virus type 1 (HIV-1) genome plays several critical roles during viral replication, including differentially establishing mRNA versus genomic RNA (gRNA) fates. As observed for proteins, the function of the RNA is tightly regulated by its structure, and a common paradigm has been that genome function is temporally modulated by structural changes in the 5'-leader. Over the past 30 years, combinations of nucleotide reactivity mapping experiments with biochemistry, mutagenesis, and phylogenetic studies have provided clues regarding the secondary structures of stretches of residues within the leader that adopt functionally discrete domains. More recently, nuclear magnetic resonance (NMR) spectroscopy approaches have been developed that enable direct detection of intra- and inter-molecular interactions within the intact leader, providing detailed insights into the structural determinants and mechanisms that regulate HIV-1 genome packaging and function.
[NMR paper] Complete backbone and DENQ side chain NMR assignments in proteins from a single experiment: implications to structure-function studies.
Complete backbone and DENQ side chain NMR assignments in proteins from a single experiment: implications to structure-function studies.
Related Articles Complete backbone and DENQ side chain NMR assignments in proteins from a single experiment: implications to structure-function studies.
J Struct Funct Genomics. 2014 Feb 18;
Authors: Reddy JG, Hosur RV
Abstract
Resonance assignment is the first and the most crucial step in all nuclear magnetic resonance (NMR) investigations on structure-function relationships in biological...
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Postdoctoral position in structure-function studies of G-protein networks in ... - Scientific American
Postdoctoral position in structure-function studies of G-protein networks in ... - Scientific American
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[NMR paper] Insights into hERG K+ channel structure and function from NMR studies.
Insights into hERG K+ channel structure and function from NMR studies.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles Insights into hERG K+ channel structure and function from NMR studies.
Eur Biophys J. 2013 Jan;42(1):71-9
Authors: Ng CA, Torres AM, Pagès G, Kuchel PW, Vandenberg JI
Abstract
The unique gating kinetics of hERG K(+) channels are critical for normal cardiac repolarization, and patients with mutations in hERG have a...
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Preparation of protein samples for NMR structure, function, and small-molecule screening studies.
Preparation of protein samples for NMR structure, function, and small-molecule screening studies.
Preparation of protein samples for NMR structure, function, and small-molecule screening studies.
Methods Enzymol. 2011;493:21-60
Authors: Acton TB, Xiao R, Anderson S, Aramini J, Buchwald WA, Ciccosanti C, Conover K, Everett J, Hamilton K, Huang YJ, Janjua H, Kornhaber G, Lau J, Lee DY, Liu G, Maglaqui M, Ma L, Mao L, Patel D, Rossi P, Sahdev S, Shastry R, Swapna GV, Tang Y, Tong S, Wang D, Wang H, Zhao L, Montelione GT
In this chapter, we...
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[NMR paper] Using NMR as a probe of protein structure and function.
Using NMR as a probe of protein structure and function.
Related Articles Using NMR as a probe of protein structure and function.
Biochem Soc Trans. 1999 Aug;27(4):701-13
Authors: Malthouse JP
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[NMR paper] NMR studies on the structure/function correlations of T-cell-epitope analogs from per
NMR studies on the structure/function correlations of T-cell-epitope analogs from pertussis toxin.
Related Articles NMR studies on the structure/function correlations of T-cell-epitope analogs from pertussis toxin.
Eur J Biochem. 1998 Jun 1;254(2):313-7
Authors: Scarselli M, Esposito G, De Magistris MT, Domenighini M, Rappuoli R, Burroni G, Bernini A, Niccolai N
A synthetic tridecapeptide, corresponding to the 30-42 fragment of the S1 subunit of pertussis toxin, has been structurally characterised by using NMR spectroscopy. The molecule...
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NMR STUDIES OF STRUCTURE AND FUNCTION OF BIOLOGICAL MACROMOLECULES - Kurt Wüthrich
NMR STUDIES OF STRUCTURE AND FUNCTION OF BIOLOGICAL MACROMOLECULES - A Lecture by Kurt Wüthrich for The Nobel Foundation, 2002
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/wutrich-lecture.pdf
A video of the lecture can be found here:
http://nobelprize.org/nobel_prizes/chemistry/laureates/2002/wuthrich-lecture.html
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Finding protein function from its NMR structure
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NMR Studies of the Structure and Function of the HIV-1 5'-Leader.
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