NMR Studies of the Ion Channel-Forming Human Amyloid-beta with Zinc Ion Concentrations
 

NMR Studies of the Ion Channel-Forming Human Amyloid-beta with Zinc Ion Concentrations

Alzheimer's disease (AD) is classified as an amyloid-related disease. Amyloid beta (A?) is a transmembrane protein known to play a major role in the pathogenesis of AD. These A? proteins can form ion channels or pores in the cell membrane. Studies have elucidated the structure of the transmembrane domain of A? ion channels. In addition, various studies have investigated substances that block or inhibit the formation of A? ion channels. Zinc ions are considered as potential inhibitors of AD. In...

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