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Default NMR in structure-based drug design.

NMR in structure-based drug design.

Related Articles NMR in structure-based drug design.

Essays Biochem. 2017 Nov 08;61(5):485-493

Authors: Carneiro MG, Ab E, Theisgen S, Siegal G

Abstract
NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery, highlighting the different levels of resolution and throughput obtainable. Additionally, the emerging field of paramagnetic NMR in drug discovery and recent developments in approaches to speed up and automate protein-observed NMR data collection and analysis are discussed.


PMID: 29118095 [PubMed - in process]



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