Abstract
NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery, highlighting the different levels of resolution and throughput obtainable. Additionally, the emerging field of paramagnetic NMR in drug discovery and recent developments in approaches to speed up and automate protein-observed NMR data collection and analysis are discussed.
Senior Research Fellow/Platform Manager (Fragment Based Drug Design) - The Conversation AU
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Senior Research Fellow/Platform Manager (Fragment Based Drug Design)
The Conversation AU
You will also provide specialised expertise in biophysical characterisation of protein-ligand interactions using Nuclear Magnetic Resonance Spectroscopy (NMR), Surface Plasmon Resonance (SPR) and other techniques as necessary. The FBDD Platform ...
Senior Research Fellow/Platform Manager (Fragment Based Drug Design) - The Conversation AU
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nmrlearner
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07-02-2015 05:49 PM
[NMR paper] NMR Screening in Fragment-Based Drug Design: A Practical Guide.
NMR Screening in Fragment-Based Drug Design: A Practical Guide.
http://www.bionmr.com//www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--production.springer.de-OnlineResources-Logos-springerlink.gif Related Articles NMR Screening in Fragment-Based Drug Design: A Practical Guide.
Methods Mol Biol. 2015;1263:197-208
Authors: Kim HY, Wyss DF
Abstract
nmrlearner
Journal club
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01-28-2015 03:22 AM
[NMR paper] Structure-based drug design: NMR-based approach for ligand-protein interactions.
Structure-based drug design: NMR-based approach for ligand-protein interactions.
Related Articles Structure-based drug design: NMR-based approach for ligand-protein interactions.
Drug Discov Today Technol. 2006;3(3):241-5
Authors: Zhang X, Tang H, Ye C, Liu M
Abstract
The realization of the powerfulness in analyzing ligand-protein interactions at the atomic resolution has made NMR techniques increasingly attractive in drug discovery and development. With some significant new method developments during the past few years,...
nmrlearner
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07-06-2014 08:28 PM
Structure-Based Drug Design
Structure-Based Drug Design
http://www.spectroscopynow.com/common/images/thumbnails/no_img.gifThe 13th Structure-Based Drug Discovery conference will feature the development of in silico technology as well as experimental approaches useful for accurately predicting and modeling the structures of proteins in structure-based drug design efforts.
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nmrlearner
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05-22-2013 04:43 PM
Postdoctoral Fellow in structure-based drug design by NMR ...
Postdoctoral Fellow in structure-based drug design by NMR ...
Postdoctoral Fellow in structure-based drug design by NMR, Heidelberg, Germany. View all science jobs and scientific careers from Nature Jobs, the premier ...
www.nature.com/.../241001-Postdoctoral-Fellow-in-structure-...
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nmrlearner
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01-15-2012 04:04 AM
[NMR paper] NMR spectroscopy in structure-based drug design.
NMR spectroscopy in structure-based drug design.
http://www.ncbi.nlm.nih.gov/corehtml/query/egifs/http:--linkinghub.elsevier.com-ihub-images-PubMedLink.gif Related Articles NMR spectroscopy in structure-based drug design.
Curr Opin Biotechnol. 1999 Feb;10(1):42-7
Authors: Roberts GC
NMR methods for the study of motion in proteins continue to improve, and a number of studies of protein-ligand complexes relevant to drug design have been reported over the past year, for example, studies of fatty-acid-binding protein and SH2 and SH3 domains. These...
NMR in structure-based drug design.
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