NMR structural analysis of the yeast cytochrome c oxidase subunit Cox13 and its interaction with ATP
 

NMR structural analysis of the yeast cytochrome c oxidase subunit Cox13 and its interaction with ATP

CONCLUSIONS: Together with functional analysis of purified CytcO, we suggest that this ATP interaction is inhibitory of catalytic activity. Our results shed light on the structural flexibility of an important subunit of yeast CytcO and provide structure-based insight into how ATP could regulate mitochondrial respiration.

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