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Default NMR Spectroscopic Approach Reveals Metabolic Diversity of Human Blood Plasma Associated with Protein-Drug Interaction.

NMR Spectroscopic Approach Reveals Metabolic Diversity of Human Blood Plasma Associated with Protein-Drug Interaction.

NMR Spectroscopic Approach Reveals Metabolic Diversity of Human Blood Plasma Associated with Protein-Drug Interaction.

Anal Chem. 2013 Aug 19;

Authors: Du Y, Lan W, Ji Z, Zhang X, Jiang B, Zhou X, Li C, Liu M


Abstract
Although blood plasma has been used to diagnose diseases and to evaluate physiological conditions, it is not easy to establish a global normal concentration range for the targeting components in the plasma due to the inherent metabolic diversity. We showed here that NMR spectroscopy coupled with principal component analysis (PCA) may provide a useful method for quantitatively characterizing metabolic diversity of human blood plasma. We analyzed 70 human blood plasma samples with and without addition of ibuprofen. By defining the PC score values as diversity index (Idiv) and the drug induced PC score value change as interaction index (Idist), we find that the two indexes are highly correlated (P
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